| Objective: To observe the clinical effect of traditional Chinese medicine of gu-ben-hua-zhuo method in the treatment of liver and kidney yin deficiency-phlegm and blood stasis type of acute cerebral infarction, to explore the mechanism of action, and to assess the safety.Methods: 60 cases of liver kidney yin deficiency-phlegm and blood stasis type of acute cerebral infarction were numbered sequentially, using a random number table divided into the observation group and the control group, each with 30 cases. The control group was treated with conventional therapy of western medicine, specific treatment plan: Aspirin 100mg/d; Atorvastatin 10mg/d; 20% mannitol 250ml/d; Oxiracetam Injection 3g/d; Cell Two Choline Injection 0.75g/d. Patients with other disease were given symptomatic treatment. The observation group was not only treated with conventional therapy of western medicine, but also treated with gu-ben-hua-zhuo method. We observe the changes of the clinical and laboratory test indexes of the two groups, and closely observe the adverse reactions of two groups during the medicine treatment.Results: ①the effect of TCM syndrome: the total effective rate of gu-ben-hua-zhuo method in the treatment of liver and kidney yin deficiency-phlegm and blood stasis type of acute cerebral infarction was 9 0.000%, significantly higher than the control group(70.000%), with statistical significance(P <0.05); after treatment, the effective rates of individual symptoms and signs of TCM of the observation group were all significantly higher than the control group, with statistical significance(P <0.05); after treatment, the TCM symptom score of the observation group was 8.933 ± 4.362, significantly lower than the control group(12.86 7 ± 4.644), with statistical significance(P <0.05). The effect of the degree of neural function defect: the total effective rate of gu-ben-hua-zhuo method in the treatment of liver and kidney yin deficiency-phlegm and blood stasis type of acute cerebral infarction was 93.333%, significantly higher than the control group(80.000%), with statistical significance( P <0.05);after treatment,NIHSS score of the observation group was 3.133±2.012, significantly lower than the control group(4.700±2.576), with statistical significance(P <0.05). ② Laboratory test indexes: gu-ben-hua-zhuo method in the treatment of liver and kidney yin deficiency-phlegm and blood stasis type of acute cerebral infarction can significantly improve some laboratory test indexes, such as to reduce terms of TC, LDL-c and FIB. The observation group shows advantages compared with the control group, with statistical significance(P <0.05); but in the term of hs-CRP, the observation group did not show its superiority compared with the control group, with no statistical significance(P> 0.05).③gu-ben-hua-zhuo method in the treatment of liver and kidney yin deficiency- phlegm and blood stasis type of acute cerebral infarction shows high security(level 1), with no obvious side effect.Conclusion: gu-ben-hua-zhuo method in the treatment of liver and kidney yin deficiency-phlegm and blood stasis type of acute cerebral infarction shows remarkable effect, safety and reliability, so it has the value of further research. |
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