The Research Of Urine Biochemistry Change Related To Human Body After Death

Objective:To provide refrence material for forensic identification of ante-mortem diseases by exploring the changing pattern of biochemical indicator in the urine of postmortem human. Method:60 urine samples of the defuncts were divided into 3 groups according to the causa mortis of forensic pathology:Cardiac disease group(n=20), muscle injuries group(n=20), other dieases control group(n=20).10 indexes(cTn-1, Mb, LDH, LDH1, AST, UAMY, Na+, K+, Cl-,Ca2+)of the urine were tested by automatic biochemical analyzer, the measured data were compared to the clinical value of normal urine and statistics analysis was made by SPSS 17.0 statistical software. Combined with the disease before, cause of death, death time, onset to death after a time, after the death of change (autolysis and putrefaction), corpse preservation, damage degree and scope, the method of sampling and sample preservation, transportation and other aspects, analysis the sample. Results:1. cTn-1: The level of cTn-1 is significantly different among the three groups(P<0.01).2. Mb: There was a statistical difference between muscle injuries group and other dieases control group(P<0.01). There was a statistical difference between cardiac disease group and B, but the difference was not significant(P<0.05). There was no statistical difference between cardiac disease group and other dieases control group(P>0.05).3. Ca2+:The difference was significant between cardiac disease group and other dieases control group(P<0.01). There was a statistical difference between cardiac disease group and muscle injuries group, but the difference was not significant(P< 0.05). There was no statistical difference between muscle injuries group and other dieases control group(P> 0.05).4. LDH、LDH1、AST、UAMY. Na+、K+、Cl+:There was no statistical difference among the 3 groups(P> 0.05). Conclusions:1. The level of cTn-1 in the urine of postmortem human may help to diagnose ante-mortem myocardial infarction.2. It is necessary to rule out the impact of myocardial infarction for the level of MYO was elevated in the condition of myocardial infarction besides crush syndrome.3. The level of Ca2+ is helpful to the diagnosis of ante-mortem myocardial infarction although it was effected by muscle injury.4. The level of LDH, LDH1, AST, UAMY, Na+, K+ and Cl- were neither statistically different among the 3 groups nor compared with the normal value.