| Objective:To investigate the clinical characteristics of premature infants with BPD of different severity, and to understand the risk and severity factors of BPD, and to analyze the correlation between PS applications and ventilation treatment.Methods:1.1 The clinical datas of 51 premature infants of BPD hospitalized in the neonatal ward of the First Affiliated Hospital of Kunming Medical University, and infants with congenital heart disease, pneumothorax, pleural effusion, diaphragmatic hernia and other severe genetic diseases.1.2 The BPD infants were divided into different groups according to gestational age, gender, asphyxia, BPD severity, PS application and ventilation treatment. The gender, gestational age, PS application, degree of asphyxia and severity of BPD were analyzed. The ventilation time, noninvasive ventilation time, invasive ventilation time were also analyzed.Results:1、Incidence of BPD:in this study, the total incidence of BPD was 3.8%; and for and for premature infants with gestational age< 32 weeks or≥32 weeks, it was 18.7% and 1.5% respectively, which was significantly different between the two groups.2、Severity of BPD:for premature infants with gestational age≥32 weeks or< 32 weeks, the percent of mild BPD were 21.0% and 41.0% respectively, and the percent of medium and severe BPD were 79.0% and 59.0% respectively, the severity of BPD in the group of gestational age< 32 weeks was significantly difference (P< 0.05). For male and female, the ratio of the mild BPD were 18% and 54%, and the proportion of medium and severe BPD were 82% and 46% respectively, the medium and severe BPD in male group was significant difference (P< 0.05).Among non-asphyxia, mild asphyxia and severe asphyxia groups, the ratio of the mild BPD were 28%,25%,33% respectively. proportion in severe BPD were 72%,75%,67% respectively,the severity of BPD in the non- asphyxia group was significant difference (P< 0.05), the others had no statistically difference (P> 0.05).3、BPD severity and ventilation treatments: among mild BPD infants, its total ventilation time was 924.86±524.59 hours, and invasive ventilation time was 72.14± 114.19 hours. Among medium and severe BPD infants, its total ventilation time was 1223.84±444.72 hours, and invasive ventilation time was 167.46±266.45 hours, the total ventilation time in the difference severity of BPD group was statistically significant (P< 0.05), the ventilation time in the difference severity of BPD group was not statistically significant (P> 0.05).4. PS and ventilation treatment: for BPD patients of gestational age< 32 weeks with PS treatment, the total ventilation time was 1482.50±552.27 hours, invasive ventilation was 269.36±248.15 hours, noninvasive ventilation time was 1213.14± 485.95 hours, the none use of PS group its total ventilation time was 1142.80± 443.81 hours, invasive ventilation was 140.25±286.27 hours, noninvasive ventilation time was 1002.55±409.57 hours, the invasive ventilation time group was statistically significant (P< 0.05), other groups were not statistically significant difference (P> 0.05).≥ 32 weeks BPD with use of PS treatment, the total ventilation time was 928.25±530.58 hours after treatment, invasive ventilation time was 61.00 ±72.69 hours, noninvasive ventilation time was 867.25±281.82 hours, the none use of PS group its total ventilation time was 838.92±221.63 hours, invasive ventilation was 26.69±47.25 hours, noninvasive ventilation time was 809.23 ±221.17 hours,all of this groups were not statistical significance (P> 0.05).5、PS and gestational age、BPD severity:< 32 weeks BPD group has no significance difference between whether to use the PS(P> 0.05);≥32 weeks BPD group has significance difference between whether use of PS (P< 0.05). Children with difference severity of BPD has no significance differences between whether use of PS(P> 0.05). NRDS group treated with PS was 79%, non treated was 21%, there was no significant difference (P> 0.05), the rate of mild BPD happened in the NRDS group was 14%, the rate of medium and severe BPD happened was 86%, there was significant difference (P< 0.05); Non NRDS group reated with PS was 19%, non treated was 81%, there was significant differences (P< 0.05), the rate of mild BPD happened in the non NRDS group was 32%, the rate of medium and severe BPD happened was 68%, there was significant difference between the two groups (P< 0.05); the different about the PS use between the NRDS and non NRDS groups were significant differences (P< 0.05), the different about the BPD happened between the NRDS and non NRDS groups were no significant difference (P> 0.05).Conclusion:1. For premature infants of gestational age< 32 weeks, the incidence of BPD was significantly greater than that of infants of the gestational age≥32 weeks; among infants of gestational age< 32 weeks, the ratio of moderate to severity BPD was significantly higher than that of gestational age≥32 weeks;2. The proportion of male patients with BPD was significantly higher than that of female patients, and BPD of male infants was also more severe than that of female;3. There is no correlation between the severity of asphyxia with the incidence of BPD and its severity;4. The total ventilation time in severe patients of BPD were higher than those in mild patients; BPD severity and invasive ventilation time relationship had no correlation; 5. The treatment of PS had no obvious effect to shorten the total ventilation time, invasive ventilation time and noninvasive ventilation time of infants with BPD. There was no significant effect on severity and incidence of BPD for PS treatment;6.NRDS was correlated with PS treatment, but with no significant correlation with the severity of BPD. |
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