| Objective:To investigate the pathogenesis and prognosis of high risk factors for acute recurrent pancreatitis.Method:The clinical data of 591 cases with acute pancreatitis(AP) from January 2012 to January 2015 in the First Affiliated Hospital of Dalian Medical University were collected from the hospital informatics database. According to the number of attacks of acute pancreatitis,the cases were categorized into different groups which were First-Episode Group(FEG) and Relapse Group(RG).A comparative analysis was done between the two groups,including the prognosis of potentially pathogenic risk factors.Results:In general, from all 591 patients with AP.(1)General data comparison: the Relapse Group included 139 cases(23.5%),of which 87 cases(62.6%) were males and 52(37.4%) cases were females. The First-Episode Group(FEG) had 452 cases(76.5%), 260 cases(57.5%) were males, 184 cases(42.5%) were females.There was no statistically significant difference between the genders(p> 0.05). The average age in the FEG and RG were 51.37 years old and 53.91 years old respectively(p> 0.05). Recurrence was compared between groups: males relapsed once every 64 cases(73.6%), with multiple relapses every23 cases(26.4%); females relapsed once 35 cases(67.3%),multiple relapses every17 cases(32.7%); There was no statistically significant difference between the two groups.(2)Frequency Risk Factors: Analysis of risk factors of RG showed 80 cases(57.6%) caused by gallstone factors, 9 cases(6.5%)by hyperlipidemia, 6 casesby dietary factors(4.3%), 22 cases(15.8%)by alcohol factors and the remaining 22 cases(15.8%) by other factors.The FEG showed 218 cases(48.2%) caused by gallstone factors, 52 cases(11.5%) by hyperlipidemia, 33 cases(7.3%) by a l c o h o l, 8 0 c a s e s b y d i e t a r y f a c t o r s( 1 7. 7 %) a n d t h e r e m a i n i n g 69 cases(15.3%)byotherfactors.The solitary alcohol factors consumption are the risk factors of recurrence pancreatitis.The results were statistically significant in recurrent attacks of acute pancreatitis.(3)Clinical Laboratory Investigations: Statistical analysis of the clinical indicators of the patients upon admission showed a positive relevant in the mean Neutrophils counts(FEG:11.82×109/L;RG:10.03×109/L;p<0.01),mean Leukocytes count(FEG:14.63×109/L; RG:11.96×109/L; p<0.01), mean Albumin(FEG: 39.29g/L;RG: 39.08g/L; p<0.05), mean plasma Calcium levels(FEG:2.05mmol/L; RG: 2.07mmol/L; p> 0.05).There was no statistically significant difference between the genders(p> 0.05).(4)Recurrence frequency comparison: Recurrence within 1 year for males was 67 cases(77%) and for females was28 cases(53.8%). Recurrence after 1 year for males was20 cases(23%) and for females was24 cases(46.2%), the difference b e t w e e n t h e t w o g r o u p s h a v e s t a t i s t i c a l s i g n i f i c a n c e( p < 0. 0 1).Conclusion:1. RAP risk factors include biliary disorders, metabolic factors and alcohol consumption, alcohol factors are high risk factors for the disease.2. AP has a high recurrence time within one year of discharge from the hospital following the preious attack and can happen mostly in male patients.3. The degree of inflammatory reaction of RAP is lighter than incipient AP level... |
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