Bone Turnover Makers,Parathyroid Hormone And Vitamin D Changes In Postmenopausal Women In Different Duration Of Menopause

Objective:To evaluate biochemical markers of bone turnover makers (BTMs) in postmenopausal women. The connection between BTMs and the years after menopausal transition was also researched in our study. BTMs affected bone mass and low bone mass caused osteoporosis, that increased the risk of fraction.Materials and methods:For this purpose, we detected carboxy-terminal telopeptide of type Ⅰ collagen (CTX), procollagen type I amino-terminal propeptide (PINP), parathyroid hormone (PTH) and vitamin D in187healthy southeastern Chinese postmenopausal women between the age of25and64years. In all the research objects, according to the duration of menopause will be divided into five groups, based on menopause duration just less than2years, more than2years to less than4years, more than4years to less than6years, more than6years to more than8years, more than8years. For the age factor’s influence on the level of four indicators, then put all objects into two groups,41to50years old and51-64year. Both two age groups, according to the duration of menopause can be divided into three groups, based on menopause duration, just less than2years, more than2years to less than5years, more than5years.Results:Serum CTX levels decreased from the short years after menopausal transition to the long years (<=2.00vs.4.01-6.00:P=0.014,<=2.00vs.6.01-8.00:P=0.008,<=2.00vs.>8.00:P=0.034).There are no significant differences about the four makers between41-50years old and51-64years old postmenopausal women. In41-50years old postmenopausal women, serum CTX levels also decreased (<=2.00vs.>5.00: P=0.023); serum PINP levels decreased, but it had no significant differences; serum PTH levels increased (<=2.00vs.>5.00:P=0.001,2.01-5.00vs.>5.00:P=0.003). However, in51-64years old postmenopausal women, serum CTX levels and serum PINP levels both decreased, but they both had on significant differences; serum PTH levels decreased (<=2.00vs.>5.00:P=0.007). As for vitamin D, it had no significant differences in overall groups.Conclusions:The women in early post-menopause (following the menopause transition <2.00years) take measures to prevent bone loss more effectively, whose bone turnover rates are remarkably accelerated.