Analysis Of The Prevalence Of Thyroid Disease With Diabetes Mellitus

Objective：To investigate the prevalence of thyroid diseases with diabetesmellitus in Endocrine and Metabolism Department of our hospital, andexplore relevant factors that may cause thyroid disease, and provideguidance for clinical diagnosis and treatment.Methods：This study retrospectively analyzed the diabetes mellitus patients inthe first hospital of Jilin University Endocrine and MetabolismDepartment from2009year in January~2010year in December,2012year in July~2013year in December, diabetic patients with thyroidfunction tests provided a total of2388cases, including T1DM, T2DM.Retrospective analysis of patients age, gender, course of disease, bodymass index, family history, thyroid function, thyroid autoantibodies,thyroid nodules, with or without diabetes complications, hypertensionhistory, hemoglobin A1c, and statistical analysis was performed on theclinical data.Results：1、The results of diabetic patients with abnormal thyroid function1)The prevalence rate of female (33.13%) was significantly higher than that of male patients (20.46%)(χ2=64.6406，P<0.0001).2) Ofdifferent ages, the prevalence rate of thyroid dysfunction was alsodifferent, and the difference is statistically significant (χ2=30.2984, P=0.0008), age≥60years were the highest prevalence.3) The prevalencerate of T1DM (46.15%) was significantly higher than that of T2DM(26.24%)(χ2=31.5252，P <0.0001).4) Without a family history ofdiabetes (28.25%), the prevalence rate of thyroid dysfunction was higherthan with a family history of (23.9%)(χ2=19.1694，P=0.0108).5) Witha prevalence rate of hypertension history (27.23%)，the prevalence ofthyroid dysfunction was higher than that of non hypertension(16.3%)(χ2=12.5433，P=0.0281).6) Comparison between different glycosylatedhemoglobin, thyroid dysfunction prevalence rate was different, and thedifference was statistically significant (χ2=108.7806, P <0.0001), poorglycemic control (≥13%) of the patients was the highest prevalence ofthyroid abnormalities.7)Comparison between different duration ofdiabetes, thyroid dysfunction prevalence was different, and the differencewas statistically significant (χ2=46.6178, P <0.0001), duration>20years, the prevalence of thyroid dysfunction in patients was significantlyhigher than the other course.8) With the increase of body mass index, andthe prevalence rate of thyroid disease gradually decreased, the differencewas statistically significant (χ2=101.2591，P <0.0001).2、 The results of diabetic patients with abnormal thyroid autoantibodies.The prevalence rate of abnormal thyroid autoantibodies in patientswith diabetes accounted for25.73%.The prevalence rate of female(34.91%) was significantly higher than that of male (14.32%)(χ2=52.3735， P<0.0001). The prevalence rate of abnormal thyroidautoantibodies in T1DM patients (59.09%) was significantly higher thanthat in T2DM patients (24.95%)(P=0.0003). The incidence of abnormalthyroid autoantibodies in Slim highest (46.43%) was higher than that ofother patients(P=0.0026). No influence of the age, course of the diabetes,blood glucose control, family history of diabetes, hypertension historywas found on prevalence of abnormal thyroid autoantibodies(P>0.05).3、The results of diabetic patients with abnormal thyroid noduleThe prevalence rate of thyroid nodules of patients with diabetesmellitus was found to be63.09%.There was trend toward a higherprevalence rate in longer duration of diabetes (χ2=12.8439,P=0.0456).No influence of the Gender, age, the type of diabetes, glycemic control,body mass index, family history of diabetes, hypertension history wasfound on prevalence of thyroid nodules (P>0.05).4、Logistic regression analysisThe abnormal thyroid function was as the dependent variable, usingmultivariate logistic regression analysis on the factors of gender, age, typeof diabetes, glycosylated hemoglobin, body mass index, course of disease, family history of diabetes, hypertension were corrected, results showedthat female and sliming was as the independent risk factors of thyroiddysfunction (P<0.05).Age, type of diabetes, glycosylated hemoglobin,course of disease, family history of diabetes, history of hypertension hadno significant relationship.5、The prevalence rate of acute complications was higher in diabetesmellitus patients combined with hyperthyroidism and abnormal thyroidautoantibody, and the prevalence rate of chronic complications washigher in diabetes mellitus patients combined with hypothyroidism.Conclusion：The prevalence rate of abnormal thyroid function in diabetesaccounted for26.68%, the prevalence rate of abnormal thyroidautoantibody accounted for25.73%, the prevalence rate of thyroidnodules accounted for63.09%.(2) Female/BMI<18kg/m2was the riskfactors of thyroid function in diabetes mellitus patients.(3)Female/T1DM/BMI<18kg/m2was the independent risk factor of diabeticpatients with abnormal thyroid autoantibodies.(4) The prevalence rate ofthyroid nodules was higher in longer duration of diabetes mellitus.(5) Theprevalence rate of acute complications was higher in diabetes mellituspatients combined with hyperthyroidism and abnormal thyroidautoantibody, and the prevalence rate of chronic complications washigher in diabetes mellitus patients combined with hypothyroidism.