Effect Of Endometrial Receptivity On Herbal Paste Do For Patients With Kidney Qi Deficiency Syndrome Of Diminished Ovarian Reserve Undergoing IVF-ET

Objective: To observe the effect of endometrial receptivity on Herbal Paste do for patients with Kidney Qi deficiency syndrome of diminished ovarian reserve(DOR) undergoing in vitro fertilization and embryo transfer(IVF-ET),and to investigate its mechanism,as to explore more effective way in adjunctive therapy of Tranditional Chinese Medcine(TCM) do for DOR patients in IVF-ET。Methods: 60 patients who conformed to the diagnosis standard in according to the random number table method divided into two groups,the experimental group of 30 cases and the control group of 30 cases.The experimental group was given oral Herbal Paste for two menstrual cycles,syndrome scores of TCM、basal serum of Follicle-stimulating hormone(FSH)、FSH/LH、Estradiol(E2)、and anti-Mullerian hormone(AMH)、the number of antral follicle were compared between before and after oral Herbal Paste;The control group without drug intervention, syndrome scores of TCM、basal serum of FSH、FSH/LH、E2、and AMH、the number of antral follicle were compared between the experimental group after oral Herbal Paste and the control group,the thickness of endometrial、type of endometrial、type of under-endometrial blood stream、PI and RI of uterine spiral arteries on the human chorionic gonadotropin(HCG) day,the total amount of gonadotropin(Gn)、the duration days of Gn、the average daily dosage of Gn、the number of retrieved oocytes、the number of 2PN and the clinical pregnancy rate were compared between two groups.Results: 1.After oral Herbal Paste of the experimental group was obviously better than before oral Herbal Paste of the experimental group and the control group in improving syndrome scores of TCM,there were significant differences.(P<0.05);2.After oral Herbal Paste of the experimental group,basal serum of FSH、FSH/LH were decreased significantly, basal serum of E2、AMH were increased,the number of antral follicle was increased significantly,there were significant differences compared with before oral Herbal Paste of the experimental group and the control group.(P<0.05);3.The thickness of endometrial of the experimental group was increased on HCG day,proportion of A-type of endometrial and Ⅲ-type of under-endometrial blood stream of the experimental group were increased on HCG day,PI and RI of uterine spiral arteries of the experimental group were decreased on HCG day,there were significant differences compared with the control group.(P<0.05);4.The total amount of Gn and the duration days of Gn of the experimental group compared with the control group were decreased significantly,there were significant differences.(P<0.05),the average daily dosage of Gn was no significant difference between two groups.(P>0.05);5.The number of retrieved oocytes of the experimental group was increased than the control group,there was significant difference.(P<0.05),the number of 2PN and the clinical pregnancy rate were no significant difference between two groups(P>0.05).Conclusion: Adjunctive therapy of Bushen Guchong Herbal Paste for patients with Kidney Qi deficiency syndrome of DOR undergoing IVF-ET can improve syndroms of Kidney Qi deficiency,increase thickness of endometrial on HCG day, improve type of endometrial and type of under-endometrial blood stream on HCG day,decrease PI and RI of uterine spiral arteries on HCG day,increase blood flow of endometrial,so as to regulate microcirculation of endometrial and improve receptivity of endometrial.