| Plant flavonoids in nature which has extensive presence, a growing number of flavonoids were found researchers at home and abroad, has also been shown flavonoids has many physiological and biological activities, and are necessary for the body of nutrients.In physiological activity of flavonoids had obvious diversity has also proved flavonoids have good physiological activity: antibacterial, anti-inflammatory, anti-liposome oxidation, anti-cancer, anti-viral, lowering blood pressure, prevent platelet aggregation, enhance immunity and so on. Also more and more researchers have conducted extensive and in-depth research and its application to the field of medical drugs, skin care products, food and additives.Anti-cancer activity of flavonoids research focus has been studied, and achieved gratifying results, flavonoids used in the pharmaceutical industry, the most widely used, the study found a large number of flavonoids significantly inhibited tumor Such flavonoids such as rutin, naringin, quercetin.Since the flavonoids found in organic synthesis of flavonoids more mature, from simple extraction and separation, to semi-synthetic modification, to total synthesis, there are many ways flavonoid for future research flavonoids compounds provide numerous synthetic methods. However, there are natural flavonoids lack of physiologically active poor, in order to achieve the intended purpose, we need to modify and improve the molecular structure of flavonoids, which screened a relatively high physiological activity of flavonoids.I read a lot of literature, found the drug sodium 1980 s listed nedocromil treatment of allergic asthma with similar flavonoids and quinolone structure, one of the most fully synthetic quinolone antibacterial drugs in anticancer effect also has better performance, for bonding process and nedocromil sodium and structural design improvements to between paracetamol and p-amino-phenol as raw material, acetylation, Claisen condensation, Fries rearrangement, amide hydrolysis, addition, dehydration ring and a series of reactions, synthesized four novel flavonoids and flavonoid derivatives have not been reported quinolone structure, which is classic and laboratory pharmaceutical carrier "polyamine chain" to connect, to improve tumor targeting novel flavonoid pharmacophore sex, and want to test its anti-cancer research, in order to obtain better anti-cancer effect. |
