| Objective:Non-erosive reflux disease,as a common digestive diseases, is easy to recur. It is generally regarded as a hete- rogeneous disease, TCM treatment based on syndrome differentiation as its basic thought has the features and advantages to the disease treatment and this is more and more notable. The purpose of the clinical study was to observe and evaluate the clinical curative effect of the esophagus ning treated non-erosive reflux disease(contradiction between liver and stomach pattern type). according to the theory of TCM and modern medicine exploring the possible mechanism of esophageal ning in the clinical treatment of the disease provides the new clinical basis for the clinical disease treatment. Methods:1.To collect 61 cases of non erosive reflux disease from the patients in Hubei province of TCM hospitals between June 2013 and June 2014.All of them conform to diagnostic criteria for non erosive reflux disease In western medicine and the contradiction be- tween liver and stomach pattern type in TCM. 61 patients meeting the test standards are divided into the control group 30 cases and treatment group 31 cases in accordance with the order.Two groups of patients is not statistically significant different on gender、age、course of the disease and treatment RDQ scores,they are comparable(P > 0.05).2.The treatment of the control group:Omeprazole sodium entericcoated metformin hydrochloride(The trade name is Ao ke, production of He pharmaceutical co., LTD., jiangsu,approved by H20 020330)10mg one time,twice a day,Half an hour before meal.The treatment of the treatment group:The mentor esophageal ning: Snakegourd fruit15 g,turmeric 12 g, frutus aurant immaturus10 g,Sue stems 15 g, magnolia officinalis 10 g,radix bupleuri 10 g,citron peel 10 g, platycodon10 g.A daily dose twice decoction, a total of 300 ml,2 times to take in the morning and evening, half an hour after the meal. According to the patient’s health and disease concur- ently to add corresponding Chinese traditional medicine.3.Two groups of patients are treated for 8 weeks in the test. To observe TCM syndrome curative effect 、improvement situation of main symptom、improvement of the life quality、the recurrence rate in 4 weeks after treatment and 12 weeks after treatment and drug safety。4.Using SPSS16.0 statistical analysis, counting data by chi-square test or Fisher’s exact probability method, grouping data measurement indexes and matching using t test to test on both sides, comparison between grade data set by rank and inspection; P values < 0.05 think inspection by the difference was statistically significant. Results:1.The syndromes curative effect of treatment group is better than that of control group: there are 9 patients who totally recovered、6 patients who were markedly effective, 8 patients who were effectively treated, 7 cases who were invalid to the treatment in the control group patients, the total effective rate of this group is 76.66.00 %;there are 15 patients who totally recovered、9patients who were markedly effective,4 patients who were effecttively treated, 2 cases who were invalid to the treatment, the total effective rate was 93.33%.,The treatment group was better than control group on the clinical comprehensive curative effect, after, P < 0.05, the difference was statistically significant with processsing by statistics software(P<O.05).2.The improving situation of main symptoms: The main symptom scores are significantly reduced in the both groups(P < 0.05), said two groups of treatment to improve the clinical symptoms and signs have effect. To accentuate when often abdominal distention, belching, full emotions not free, not to eat, good heave a deep sigh, the diagnosis of noisy symptoms improvement, the effect of treatment group is better than the control group(P<0.05), the sy mptoms of acid reflux, heartburn to improve curative effect.3.Evaluation of the recurrence rate : 4 weeks towards after trea-tment, the treatment group recurrence rate was 3.57%, the rate in the control group was 14.29%, statistically significant(P < 0.05). 12 weeks of treatment group recurrence rate was 14.29%, while the control group 23.81%, by statistical comparison, P < 0.05). Shows that the recurrence rates of 4 weeks and 12 weeks after treatment of treatment group are both lower than them of the control group. This prompt s recent and forward curative effect is better.4. Evaluation of drug safety : during treatment with the control group with 1 case occurred occasionally dizziness, exclusion of other risk factors, the medicine to continue to the end of the treatment cycle, not happen again after drug withdrawal. Three routine, electrocardiogram(ecg), liver and kidney function completed before and after treatment, the control group have abnormal GGT in 1 case, more than the normal range. Conclusion:The Traditional Chinese medicine formula esophageal has good clinical effection to non-erosive reflux disease(The contraction between liver and stomach pattern) has good clinical effect, Focusing on the basic pathogenesis of the contraction between liver and stomach, taking liver and stomach(spleen) as the core, and transporting Qi of one person.Compare with western medicine treatment, it can significantly improve the clinical symptoms and the symptoms of anxiety, and the recurrence rate is low, adverse reaction is little.It deserves further research and application for clinical reference. |
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