Clinical Study Of Zhibai Dihuang Decoction In The Treatment Of Postoperative Endometriosis Patients After The Use Of Zoladex Induced Perimenopausal Symptoms

Objective:Through the observation of Zhibai Dihuang Decoction in treating Endometriosis(EMS) of gonadotropin releasing hormone analogues used in postoperative patients(GnRH-a) the clinical curative effect of the treatment of perimenopausal symptoms appear, and provide a theoretical basis for clinical and treatment method.Methods:The study was divided into two parts of theoretical research and clinical research.Theoretical research: Analysis of relevant literature, to summarize the advances of traditional medicine and modern medicine diagnosis and treatment of perimenopausal symptoms.Clinical research: All cases of postoperative menstruation first days to Enoch subcutaneous injection at a dose of 3.6mg/4 weeks, a total of 12 weeks. Norest first needle injection after 1 months follow-up, emergence of perimenopausal symptoms, in accordance with the inclusion criteria were 60 cases. According to the random principle, the experimental group and the control group were randomly divided into two groups. The experimental group to Zoladex treatment also oral Zhibai Dihuang Decoction, daily 1 agent, water frying take juice 300ml,2 times a day, for taking 3 months. The control group continued to Zoladex during treatment does not add any drug. Before treatment, first months, second months, third months after treatment, KMI score, blood LH, E2, FSH, endometrial thickness and uterine arterial blood flow (RI, PSV) were compared.. The observation time of the two groups was 3 months.Results:(1)Before treatment, two groups of patients with age, menstrual cycle, the menstrual period, EMS staging criteria ,the scores of KMI, FSH, LH, E2, endometrial thickness, uterine artery flow (PSV, RI) showed no significant differences (P> 0.05), comparable; (2) the KMI scores were compared: 1 month, treatment the test group after treatment after 2 months and 3 months after treatment compared with before treatment, KMI score difference was statistically significant (P< 0.05). The control of 2 months, 1 month after treatment, KMI score compared with before treatment the differences were statistically significant (P< 0.05), 3 months after treatment, there were no significant differences in KMI score and before treatment (P> 0.05). Between the two groups after treatment compared, there is a significant difference (P< 0.05); (3) compared the blood FSH, LH, E2:comparison of two groups in each group,2 months and 1 month of treatment, after treatment, the difference had no statistical significance (P> 0.05), after 3 months of treatment with after treatment the difference was statistically significant (P< 0.05). The experiment group and the control group had no statistical significance in comparison to 2 months,1 month after treatment the difference (P> 0.05), compared to 3 months after treatment, the difference had statistical significance (P< 0.05); (4) the thickness of endometrium, uterine artery flow (PSV, RI): comparing the two groups respectively, In comparison, 1 month after treatment, 2 months of the endometrial thickness, uterine artery flow (PSV, RI) compared with that before treatment there were no significant differences (P> 0.05), after treatment compared with difference thickness for 3 months before the endometrium was statistically significant (P< 0.05), uterine artery blood flow (PSV, RI) no significant difference with before treatment (P> 0.05). The experiment group and the control group after treatment for 1 month, 2 months, endometrial thickness, uterine artery flow (PSV, RI) were not significant (P>0.05), test group 3 months after treatment of endometrial thickness compared with the control group, the difference was statistically significant (P< 0.05), uterine arterial blood (PSV, RI) had no significant difference(P> 0.05).Conclusion:With Zhibai Dihuang Decoction in the treatment of EMS in patients with after the use of Zoladex induced peri menopausal symptoms, the curative effect is exact, effectively reduce the KMI score, and can promote the recovery of blood FSH, LH, E2 and endometrial hickness. Speculated that its therapeutic effect is the regulation of the hypothalamic pituitary ovarian axis through the prescription and play a role, but the specific mechanism needs further animal experiment and pharmacological experiments to clear.