The Value Of Detecting SOD With Combined Others In The Diagnosis Of Thoracic Tuberculous(TB)

Objective: To explore the clinical value of SOD combined with NLR, PCT or ADA in PTB, or TPE by detecting SOD levels in thoracic tuberculous. Methods: Automatic biochemistry analyzer, blood cell analyzer, immunosorbent double antibody sandwich were used to detect SOD,blood leukocytes,neutrophils,lymphocytes, calcitonin levels in 132 cases of PTB and 103 patients with CAP, respectively. The difference between the two groups were compared and the sensitivity and specificity of SOD with combined PCT or NLR in the diagnosis of PTB were assayed. The levels of pleural effusion or serum ADA, SOD in 51 cases of tuberculous pleurisy or 46 patients with malignant pleural effusion were determined by immunosorbent double antibody sandwich assay, the sensitivity and specificity of the joint detection in the diagnosis of TPE were observed. Results:1.SOD、PCT、NLR levels in the cases of 132 PTB patients are significantly lower than that in patients with CAP(P < 0.05);lymphocyte from PTB and CAP has no obvious difference(P > 0.05).The sensitivity and specificity of combined detection of SOD,NLR and PCT were 94%,90% respectively in diagnosis of PTB. The area under the ROC curve for SOD,NLR joint PCT is significant great(>0.90). 2. SOD levels in pleural effusion and serum from TPE were significantly lower than that from MPE(P<0.05).ADA in pleursl effusion from TPE group was obviously higher than that from MPE group(P < 0.05), serum ADA level has no obvious difference between TPE and MPE(P > 0.05), pleural effusion ADA/serum ADA in TPE group is significantly higher than that in MPE group(P < 0.05).Pleural effusion SOD < 84 u/m L is an optimal cut-off value to discriminate TPE from MPE(sensitivity 88%, specificity 79%); pleural effusion ADA/serum ADA > 1 distinguish TPE from MPE actively(specificity 88%, specificity 84%).The sensitivity and specificity of combined detection of Pleural effusion SOD, pleural effusion ADA/serum ADA were 91%,89% respectively in diagnosis of TPE. Conclusion: The clinical value of single SOD detection in the diagnosis of thoracic tuberculous is limited,while combined detection is beneficial to improving the diagnosis performance as well as increasing the diagnosis rate for thoracic tuberculous. The detecting SOD with PCT, NLR or ADA is an ideal way in the diagonis of thoracic tuberculous.