Study On The Correlation Between P38MAPk And 25-hydroxy Vitamin D After Acute Brain Injury

[Objective]:Study the relationship between P38MAPK and 25 (OH) D after acute brain injury.[Methods]:112 cases of acute brain injury patients during April 2014 to April 2015 are collected (63 males and 49 females, aged between 45 to 70, mean age 51.76 ± 9.64), the patients are divide into four groups, including traumatic brain injury group (32 cases), cerebral hemorrhage group (38 cases), cerebral infarction group (42 cases) and control group (23 cases) for study, the patients’blood were drew 6h,24h,72h,7d, 14d after admitted to hospital to detect P38MAPK and 25 (OH) D qualitatively and quantitatively, according to the relevant data result, the relationship between P38MAPK and 25-hydroxy vitamin D after acute brain injury can be analyzed.[Results]:1.The expression of serum P38MAPK content in TBI group, cerebral hemorrhage group and cerebral infarction group at 6h was gradually increased, significantly increased at 24h, and reached to the peak at 72h,72h-7d maintained a high platform, at 14d, the expression was basically similar to the control group, in particular, cerebral hemorrhage group at 72h (3.965±0.825), brain trauma group at 72h (3.865 ± 0.703), cerebral infarction group at 72h (3.526 ± 0.613), their differences with the control group were statistically significant (p<0.05);2.The P38MAPK content in these three groups at 24h-72h were significantly higher than the control group, and their differences were statistically significant (x2=27.265, P< 0.01).3.The expression of 25 (OH) D content in serum in the groups of TBI, cerebral hemorrhage and cerebral infarction were gradually decreased at 6h, and significantly decreased at 24h, and reached to the peak at 72h,72h-7d remained at a low level,7d expression gradually increased, at 14d, the expression was basically similar to the control group, in particular, cerebral hemorrhage group at 72h (6.82 ±0.88), brain trauma group at 72h (8.19 ±0.23), cerebral infarction group at 72h (7.71 ± 0.21), their differences were statistically significant (p<0.05);4.The 25 (OH) D content in these three groups at 24h-72h was significantly lower than the control group, the differences were statistically significant (x2=25.183, P<0.01).;5.The expression of IL-17 and IL-23 and 25 (OH) D had a negative correlation in the groups of TBI, cerebral hemorrhage, and cerebral infarction after acute brain injury;6.25 (OH) D and IL-17 had a negative correlation (β=-0.298,95%,CI:-1.182--0.422, P< 0.001), with statistical significance;7.25 (OH) D and IL-23 had a negative correlation (β=-0.312,95%, CI:-7.198～-3.219,P< 0.001) with statistical significance,;8. IL-17 and IL-23 had a positive correlation; (β= 0.517, CI:0.062～ 0.112, P< 0.001), with statistical significance.[Conclusion]:1. P38MAPK and acute brain injury has synergistic effect, can be defined as the early stage of acute cerebral injury index.2.25 (OH) D has a negative correlation with acute brain injury, can be defined as the early stage of acute cerebral injury index.3. The changes of P38MAPK and 25 (OH) D 24h to 72h after acute brain injury can be regarded as an aiding method to define the time of early brain injury.