Neurobehavioral, Imaging And Serum Protein Spectrum Analysis In Patients Wih Hypertensive Intracerebral Hemorrhage

Objective:This study aimed to investigate the change of neuro-ethology, imaging, blood pressure and serum protein in patients with hypertensive cerebral hemorrhage in order to provide experimental basis for studying hypertensive cerebral hemorrhage disease. Method:43 cases (male:33 cade, female:10 cases, age:32-85, average age:57.93±13.12), were diagnosed with hypertensive cerebral hemorrhage in neurosurgery of Kunming first people’s hospital during April 2014 to October 2015. According to the grade of hypertension,43 patients were divided into hypertension level 1 (group A), level 2 (group B) and level 3 (group C), and group A, B and C was divided into male and female subgroup on the basis of sex. The acute phase of cerebral hemorrhage (onset time<24 hours) of patient was performed for NIHSS scores, head CT examination, measurement of cerebral hemorrhage volume and serum was collected for protein microarray analysis. Statistical analysis using ANOVA. Results:(1) The results of NIHSS scores showed that the NIHSS scores of hypertensive cerebral hemorrhage in group A and B were lower compared with group C (p<0.05), while there is no statistical difference between group A and B (p>0.05).The NIHSS scores of male patients with hypertensive cerebral hemorrhage in group A and group B were lower compared with group C, which were statistically different (p <0.05). The NIHHSS scores of female patients with hypertensive cerebral hemorrhage were not performed for statistical analysis with quantity shortage. (2)The results of cerebral hemorrhage volume was detected by craniocerebral CT, indicated that the cerebral hemorrhage volume of patients in group C was higher compared with group A and B (p<0.05), while there was no statistical difference in group A and B (p>0.05). The cerebral hemorrhage volume of male patients with hypertensive cerebral hemorrhage in group C was higher compared with those in group A and B (p <0.05), but there is no statistical difference in group A and B (p>0.05). The cerebral hemorrhage volume of female patients with hypertensive cerebral hemorrhage was not performed for statistical analysis due to quantity shortage. (3) The analysis of serum protein chip demonstrated that there were 4 proteins at 7-14 down-regulated fold change and 8 proteins at 2-4 down-regulated fold change after hypertensive cerebral hemorrhage. There are 6 proteins at more than 50 upregulated fold change,9 proteins at 20-40 upregulated fold change,25 proteins at 6-10 upregulated fold change,51 proteins at 4-6 upregulated fold change and 121 proteins at 2-4 upregulated fold change. Conclusion:(1) After hypertensive intracerebral hemorrhage, the higher the blood pressure of patients, the higher the NIHSS scores, the more serious neural function damage, the more bleeding capacity.And NIHSS score and the cerebral hemorrhage volume have some relevance. (2) After hypertensive intracerebral hemorrhage, patients of neurological injury may be related to family protein changes.