Investigation Of Mother To Child Transmission Of Hepatitis B Virus And Construction Of Blocking Model In Jilin Area

Objective:An investigation of essential situation in culture and economic conditions of pregnant women with hepatitis B virus in Jilin area of Jilin Province, China was taken for blocking-up measures of preventing hepatitis B virus in mother to child transmission. The data was analyzed to look for factors which obviously affect the mother to child transmission of hepatitis B virus to build the blocking model about mother to child transmission of hepatitis B virus in Jilin area.Methods:The pregnant women with hepatitis B virus infection and their babies were the investigation subjects, who were confined in Jilin Central Hospital, Affiliated Hospital of Jinlin Medical College from January 1,2009 to January 1,2013. The methods of investigation were taken by phone or qq in one-to-one. The results were analyzed by SSPPSV19.0.Results:(1)The basic information of pregnant women with hepatitis B virus and blocking measures of mother to child transmission in Jilin area:There were 888 cases of pregnant women with hepatitis B virus in the investigation. Among them,417 pregnant women were selected as the intensive investigation targets to get the basic information of their husbands and of whether the babies were injected with HBIG. It was not different in natural conditions and information of their husbands between the heathy control and the pregnant women with hepatitis B virus. Compared with the healthy pregnant women, It was different in occupation and pregnancy, that the pregnant women with hepatitis B virus did not have stable jobs and just the first pregnancy.In order to block the probability by mother to child transmission, There are 540 pregnant women were injected with HBIG among the 888 investigation targets, which occupied 60.81% of all pregnant women with hepatitis B virus. In the delivery mode,692 pregnant women choosed cesarean section, standing for 77.93%. Among the 893 babies,877 (98.21%) were injected with HepB, and 795 (89.03%) babies were injected with HBIG within 24 hours after birth. There were 59 babies who were detected hepatitis B virus in cord blood after adopting blocking measures, standing for 6.61%.In the 417 intensive investigation targets, there were 263 pregnant women who were injected with HBIG normatively(63.07%). And 325 pregnant women choosed cesarean section, which occupied 77.94%. In the 420 babies who were bomed from 417 pregnant women of HBV, there were 410 and 378 who were injected with HepB and HBIG respectively within 24 hours, standing for 97.62% and 90.00%. And 29 babies were infected with hepatitis B virus by detecting cord blood, which occupied 6.90% of the babies. Then 396 and 105 babies were injected with HepB and HBIG, which occupied 94.29% and 20.71%. There were 213 mothers who choosed artificial feeding in nursing way, which occupied 51.08%.(2)The factors of impacting mother to child transmission of hepatitis B virus:Through analyzing natural information, basic information of husbands and the related situation of the pregnancy, it was found that mother to child transmission of hepatitis B virus was mostly affected by educational level of pregnant women and husbands, the age of pregnant women, whether the babies were injected with HepB and HBIG, and nursing way.(3)Building of the blocking model about mother to child transmission of hepatitis B virus:Through analyzing the factors which affect mother to child transmission of hepatitis B virus, a reasonable blocking model about mother to child transmission of hepatitis B virus was established The whole model could be divided into the blocking ones before, during, and after pregnancy. Then according to tested dimension of pregnant women with hepatitis B virus, they were divided into Hepatitis B HBeAg pregnant women and other hepatitis B virus pregnant women.Gonolusion:Through analyzing the investigation between pregnant women with hepatitis B virus and the healthy, it is found that there is no obvious difference in the daily life, but in the employment, discrimination of employment is existed. The rate is lower that pregnant women with hepatitis B virus were injected with HBIG during pregnancy due to expensive HBIG and the not obvious blocking effect Injected HepB and HBIG normatively ensure the blocking effect of mother to child transmission of hepatitis B virus. After birth, the babies should be injected with HBIG. In the nursing way, compared with healthy pregnant women, the most of pregnant women with hepatitis B virus choose artificial feeding to reduce the rate of mother to child transmission of hepatitis B virus.