Etiology Feature And Antibiotic Sensitivity Analysis Of Neonatal Sepsis

Objective:To learn about neonatal sepsis infection situation in the local Neonatal Intensive Care Unit, the proportion of different gestational age and weight, analyze pathogens distribution blood culture in early-onset and late-onset sepsis and drug susceptibility, to provide basis for clinical medication.Methods:Selected the neonatal blood culture positive cases form 2013.1 to 2014.12 in first hospital of Jilin university. Inclusion criteria: admission age of< 24 h after birth; Accord with standard diagnosis of neonatal sepsis, which also conform to the following two conditions: the first is clinical manifestation, temperature changes, jaundice, and poor response and laboratory examination of WBC increase, rate of band cell increase or higher CRP; another require is take blood culture before use antibiotics, or produce the same conditional pathogenic bacteria twice. Exclusion criteria:congenital malformation, such as trachea esophageal fistula, intestinal abnormalities, severe congenital heart disease need operation treatment; except the other with chromosome diseases or genetic metabolic disease; Accord with the object of study, the record of the gestational age, sex, weight, time, blood culture results, drug susceptibility analysis and outcome, based on gestational age divided into small premature, near-term infant, term infant, based on birth weight divided into very low birth weight, low birth weight and ≥ 2500g, based on the onset time divided into early-onset sepsis and late-onset sepsis. Data using SPSS 19.0 were analyzed.Results:1. In the review of 163 cases, small premature 81 cases, near-term infant 33 cases and term infant 49 cases, early-onset sepsis in 82 cases,81 cases of late-onset sepsis.2. Between early-onset sepsis and late-onset sepsis, more males than females infected, two groups had no significant difference (P> 0.05). With gestational age assessment, both with small premature as the main crowd, two groups had no significant difference(P>0.05). With birth weight assessment, both extremely low birth weight,low birth weight and 2500 g patients are roughly the same, had no statistical difference (P>0.05).3. In all cases of neonatal sepsis, gram-negative bacteria were 59.5%, 38.7% gram-positive bacterium, fungus were 1.84%. Klebsiella pneumonia, E.coli, epidermis staphylococcus was the main pathogenic bacteria. In early-onset sepsis, coagulase negative staphylococcus take the main part, which accounted for 39% of early-onset sepsis, epidermis staphylococcus as the main pathogenic bacteria, E. coli (31.7%), In late-onset sepsis, pneumonia klebsiella bacteria is the most, accounts for 44.4%.Fungal infection were candida albicans, and all cases is late onset sepsis.In the death cases,the early-onset sepsis was higher than late-onset sepsis, klebsiella pneumonia is the main pathogenic bacteria.4. The drug sensitivity results better sensitivity for staphylococcus antibiotics was sulfamethoxazole, levofloxacin and rifampicin, linezolid and vancomycin 100% sensitive. Better sensitivity for gram-negative bacteria is amikacin, Meropenem and Imipenem is highly sensitive. Candida albicans to common antifungal drugs no resistance.Conclusion:1. Almost the same incidence of early-onset sepsis and late-onset sepsis. Dead manily occur in the early-onset sepsis.2. Small premature is the main crowd..3. The pathogen of gram-negative bacteria is most, klebsiella pneumoniae for first place.4. Coagulase negative staphylococcus and E. coli are main pathogen in early-onset sepsis; klebsiella pneumonia is the most in late-onset sepsis.