Clinical Research On The Relationship Between Coagulation Parameters And Clinical Characteristics Of Breast Cancer Patients

Objective:To explore the relationship between coagulation parameters and clinical characteristics of breast cancer patients.Methods:A total of354cases of histopathologically confirmed breast cancer patients and207cases of breast fibroadenoma patients in the First Affiliated Hospital, College of Medicine, Zhejiang University from January2013to December2014were included in this retrospective study. The information of patients’age and clinical characteristics including TNM stage, results of immunohistochemistry (ER (Estrogen receptor)、PR (Progestogen receptor)、Ki-67and Her-2(Human epidermal growth factor receptor-2) expression) and coagulation parameters (Pit (Platelet)、PT (Prothrombin time)、 TT (Thrombin time)、APTT (Activated partial thromboplastin time)、D-D (D-dimer) and Fib (Fibrinogen)) of before treatment were collected. The relationship between coagulation parameters and clinical characteristics of breast cancer were analyzed.Results:1) Breast cancer patients had shorter APTT (P<0.05) and PT (P<0.05), higher D-D level (P<0.05) and lower Plt counts (P<0.05) than compared with breast fibroadenoma patients,;2) Stage Ⅳ breast cancer patients had higher Plt counts(P<0.05), higher D-D level (P<0.05), higher Fib level (P<0.05) and shorter TT (P<0.05) than patients with stage Ⅰ, Ⅱ and Ⅲ, respectively. Except D-D level rose with the stage increasing and had statistical difference, there was no statistical difference among stage Ⅰ, Ⅱ and Ⅲ of Plt counts, Fib level and TT. Further analyzed, Plt counts of breast fibroadenoma patients was higher than patients with stage Ⅰ-Ⅲ breast cancer (P<0.05) but lower than stage Ⅳ breast patients (P<0.05),3) For all breast cancer patients, patients with Ki-67≥14%had shorter APTT and PT than Ki-67<14%patients with (P<0.05). Breast cancer patients with Her-2positive had shorter APTT than breast cancers with Her-2negative (P<0.05).4) For invasive breast cancer patients, patients with Ki-67≥14%had shorter APTT and TP than Ki-67<14%patients with (P<0.05).Luminal A type invasive breast cancer patients had longer APTT than Luminal B type (P<0.05), ERBB2type (P<0.05) and Basal-like type (P>0.05) breast cancer patients. Luminal A type invasive breast cancer patients also had longer PT than Luminal B type (P<0.05), Basal-like type (P<0.05) and ERBB2type (P>0.05) breast cancer patients.Conclusion:Breast cancer patients, especially stage IV breast cancer patients, are prone to be in hypercoagulable state. Serum level of D-D was closely related with TNM stage. APTT and PT was closely related with Ki-67and Her-2status. Coagulation parameters might be used as predictors of clinical characteristics of breast cancer.