Meta-Analysis On Head Injury And Risk Of Alzheimer’s Disease

Objective:To determine, using a systematic review of case-control studies, whether head injury is a significant risk factor for Alzheimer’s disease. To discuss the relationship between brain injury and Alzheimer’s disease.Methods:A predefined inclusion criterion specified case-control studies eligible for inclusion. A comprehensive and systematic search of various electronic databases, up to August2014, was undertaken. Related articles searched from the databases such as PubMed, Ovid, Springer, VP and CNKI were collected and strictly evaluated;8case-control studies were identified that met the inclusion criteria, Statistical analysis using Review Manager5.2software provided by Cochrane, the binary classification variables using Mantel Haenszel merger analysis, analysis model is Fixed Effect, inspection level is P<0.05; Using X2to check the heterogeneity of each independent research, heterogeneity inspection level P<0.1;Results:334papers are retrieved through internet. According to the incorporated into and exclusion criteria, meta-analysis of the8studies conducted since1995are included. Total sample size is2436cases,959case group and1477control group. However, analysis of all8case-control studies was significant (OR1.4795%CI1.08to1.99), P=0.01), indicating an excess history of head injury in those with Alzheimer’s disease. The risk of head injury in those with Alzheimer’s disease is more significant in males (males:OR2.29,95%CI1.47to2.06; females:OR0.91,95%CI0.56to1.47).Conclusion:This study provides support for an association between a history of previous head injury and the risk of developing Alzheimer’s disease, history of previous head injury has significant correlation with Alzheimer’s disease in male patients, but not in female patients.