Influence Of Long-acting Gonadotrophin Releasing Hormone Agonist To The Outcome Of Frozen Thawed Embryo Transfer Cycle In Patients With Polycystic Ovarian Syndrome

Objective: To make a comparison of hormone replacement treatmentwith/without pretreatment of long-acting gonadotrophin releasinghormone agonist (GnRHa) pituitary down-regulation; then evaluate theapplication value of GnRHa for frozen thawed embryo transfer (FET)cycle in polycystic ovarian syndrome (PCOS) patients.Materials and methods: Retrospective review of115FET cycles ofPCOS patients performed in Reproductive center, Department ofGynaecology＆Obstetrics, Second Affiliated Hospital of JilinUniversity from January2013to December2014. The patients weredivided into group A (GnRHa+E+P, n=39) who received GnRHa pituitarydown-regulation and group B (E+P, n=76) according to endometriumpreparing protocols. For patients in two groups, compare the age,duration of infertility, body mass index (BMI), number of frozen embryoinplantation cycles, mean serum luteinizing hormone, progesterone andestrogen level on the first day of receiving progesterone, thickness ofendometrium on FET day, embryo recovery rate, high-quality embryorate, number of embryos transferred, implantation rate of embryostransferred and clinical pregnancy rate.Result: There was no significant differences in patients’ mean age, meanduration of infertility, mean BMI, mean cycle numbers, mean endometrialthickness on FET day, mean progesterone level and estrogen level,embryo recovery rate, high-quality embryo rate, mean number of embryos transferred (p>0.05). However, group A achieved significantlylower mean LH level (1.15±0.87vs10.76±5.43mIU/ml, p<0.05), lowermean E2level (39.66±15.71vs49.10±24.56pg/ml, p<0.05), higherimplantation rate of embryo transferred (45.06%vs32.20%, p <0.05) andhigh clinical pregnancy rate (61.54%vs42.11%, p <0.05) compared withgroup B. The abortion rate of first trimester and ectopic pregnancy rate issimilar in both group A and B.Conclusion: Hormone replacement cycle with long-acting GnRHapituitary suppression is an effective and feasible method for artificial FETcycle of PCOS patients.