| Objective:The randomized controlled clinical study was designed to investigatethe causes of portal system thrombosis after splenectomy for portalhypertension due to cirrhosis in patients, and analyze the relevantinfluencing factors.Methods:From May2013to October2014, the clinical data of131patients withhypertension due to cirrhosis receiving splenectomy in our departmentwere retrospectively analyzed. The131cases were divided into thethrombosis group and non-thrombosis group. The patient’s age, gender,diameter of portal vein, spleen size, liver function, postoperativecomplications, the blood flow rate and pressure of postoperative portalvein, platelet count and prothrombin extending time before and aftersurgery were examined and analyzed, and estimate the relevant factors ofthrombosis.Results:Portal vein thrombosis (PVT) occurred after operation in20of131patients (20/131,15.27%). The diameter of portal vein, spleen size,postoperative complications, blood flow and pressure of portal veinbefore and after surgery of the patients of PVT after splenectomy weresignificantly associated to PVT, the difference was statistically significant (P<0.05). The patient’s age, gender, liver function, platelet count beforeand after the surgery, blood flow of portal vein before surgery andprothrombin extending time before and after surgery were not associatedwith PVT, the difference was not statistically significant (P>0.05).Conclusion:The wider of portal vein diameter, larger of spleen, the more ofpostoperative complications, slower of portal vein blood flow aftersurgery and smaller of portal vein pressure before and after surgery, themore likely to occur PVT in the patients with hypertension due tocirrhosis receiving splenectomy. Consequently, doing variouspostoperative detection with above indicators timely can reduce theformation of PVT in the patients and promote the rehabilitation ofpatients. Well-designed randomized studies on the PVT are urgently andneeded. |
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