The Study Of The Effectiveness And Safety Of Dexmedetomidine In Patient-controlled Intravenous Analgesia After Spinal Surgery

Objective:To explore the effectiveness and safety of dexmedetomidine combined withsufentanil in postoperative patient controlled intravenous analgesia of spinal surgery.Methods:Sixty patients who underwent elective lumbar surgery were randomly divided intotwo groups:dexmedetomidine combined with sufentanil analgesia group(groupD,n=30) and sufentanil group (group S,n=30).All patients received total intravenousanesthesia,group D used dexmedetomidine combined with sufentanil forpostoperative patient controlled intravenous analgesia,S group used sufentanil forpatient controlled intravenous analgesia.Background doses of two groups were all2ml/h,self-controlled doses each0.5ml,locking time15min.we recorded blood lossvolume, the volume of rehydration fluids and operation time of two groups ofpatients during the operation;In addition,there were VAS score of pain at2,6,12,24after the operation,Ramsay sedation score,the usage and adverse reactions ofanalgesia pump.Results:1There were no statistical differences in general conditions of two groups ofpatients including gender,age,weight,blood loss volume,rehydration fluids andoperation time and so on（P＞0.05）.2VAS score of pain of group D within24h after the operation was significantlylower than that of group S,and the difference was statistically significan（tP＜0.05）；The difference of VAS score of pain at24h and48h in two groups was notobvious,there was no statistically significant（P＞0.05）.3Ramsay sedation score of group D within24h after the operation was significantly higher than that of group S,and the difference was statisticallysignificant（P＜0.05）;The difference of Ramsay sedation scores of two groups in24h~48h after the operation was not obvious,there was no statistically significantdifference（P＞0.05）.4Press times of analgesia pump of group D was obviously less than that of groupS,and the difference was statistically significant（P＜0.05）.5Respiratory depression,excessive sedation and bradycardia didn’t happen in thetwo groups.The number of the patient who had nausea,vomiting,chills in group Dwas obviously less than that in group S,and the difference was statisticallysignificant（P＜0.05）.Conclusion:The application of dexmedetomidine combined with sufentanil postoperativepatient-controlled intravenous analgesia of spinal surgery is safe and effective.Itrelieves pain at the same time,decreases the dosage of sufentanil and reduces theincidence of adverse reactions.