Treatment Of Osteoporosis Patients With Vitamin K₂and The Effect Of Vitamin K₂on Coagulation Function

Objective:Treatment of osteoporosis patients with vitamin K2andthe effect of vitamin K2on coagulation functionMethods: Chose20cases with primary or secondary osteoporosispatients in our hospital clinic(18females,2males, aged44-80years old,mean age58.3).They were randomly divided into A,B two groups of10cases. Exclude severe liver disease, other metabolic bone diseases andbone metabolism influence of drugs; nearly10days taking any calcium,active vitamin D. A group of patients given oral vitamin AD (100units/3times a day) combined with Caltrate D (CaCO31.5g/once a day); GroupB patients given oral vitamin K2(GuLiKang15mg/three times a day)and vitamin AD (100units/3times a day) and Caltrate D (CaCO31.5g/once a day), treatment lasted twelve months. All observed objects weremeasured the BMD in0,6,12months on medication (dual-energy X-rayabsorptiometry measured bone mineral density in the lumbar spine andboth hips), Bone mineral density (BMD),prothrombin time (PT),activatedpartial thromboplastin time (APTT),thrombin time(TT)and fibrinogen(FIB)were all determined.Result: After12months of treatment,bone mineral density of twogroups were significantly higher than before treatment,and bone mineraldensity of group B increased,compared with group A, abnormal bloodclotting mechanism of group A and group B does not appear use of it.Calcium combined with Vitamin K or Vitamin D were nerve appearedhypercalcemia.Conclusion:1.Vitamin K can increase bone mineral density；2.Abnormal blood clotting mechanism does not appear afterlong-term use of it；3.It can be combined with Vitamin D and calcium combined forosteoporosis.