Fabrication And Characterization Of Poly (L Lactic Acid)/Zirconium Dioxide/Soybean Protein Isolated Nanofibrous Membranes

Electrospinning technique was used to fabricate the poly (L-lactic acid)complex fibers, including chloramphenicol (CP)-poly (L-lactic acid)/zirconiumdioxide (ZrO2) and Nisin-poly (L-lactic acid)/soybean protein isolated(SPI)/zirconium dioxide nanofibrous membranes. In this paper, the influence ofdifferent electrospinning parameter and ratio of each component on thenanofibers structure, degradability, antimicrobial activity and drug release abilitywere characterized.Electrospinning technique was used to fabricate chloroamphenicol loadedpoly (L-lactic acid)/ZrO2(CP-PLLA/ZrO2) nanofibrous membranes. Themorphologies of the nanofibers were investigated by electron microscopy (SEM).When tio-to-collectotor distance (TCD) was10cm, voltage was18kV, thecontent of ZrO2was2%and the CP content was8%, the microscopy ofnanofibers was better. The results of Fourier infrared spectroscopy (FTIR),scanning photoelectron spectroscopy (XPS) and thermogravimetric analysis (TG)showed that the existence of hydrogen and Zr–O–C bonds between PLLA and ZrO2units improved the thermal stability of PLLA. The CP-PLLA/ZrO2nanofibrousmembranes revealed better antimicrobial activity against S. aureus. and well controlledrelease.Electrospinning technique was used to fabricate Nisin-poly (L-lacticacid)/soybean protein isolated (SPI)/zirconium dioxide nanofibrous membranes.SEM result showed that when the content of SPI and Nisin was10%and12%respectively, the microscopy of nanofibers was better. PLLA, ZrO2and SPI canconbine together with hydrogen bonds, and the addition of SPI and ZrO2canbreak the crystal properties of PLLA. Degradation of PLLA/ZrO2/SPI was speed upwith the addition of SPI, and degradation shortened for4d when10%SPI was added in.Nisin-PLLA/ZrO2/SPI nanofibrous membranes revealed well controlled release andbetter antimicrobial activity against S. aureus.