Association Between Chronic Kidney Disease And Hyperuricemia

Objective: To explore the association between chronic kidney disease andhyperuicemia. Aim to test whether serum uric acid is a risk factor for chronic kidneydisease and in order to help clinicians to improve the understanding of hyperuricemia,which could prevent the occurrence of chronic kidney disease by early clinicalintervention on hyperuricemia.Methods: In a cross-sectional study,198patients from June2012to December2013in the nephrology department in Yijishan Hospital of Wannan Medical Collegewere recruited. The modification of Diet in Renal Disease (MDRD) equation was usedto count glomerular filtration (GFR) values. ALL participants were divided into fourgroups. The first group(control group):uric acid values were5.3mg/dl or less, Thesecond group: uric acid values were5.4-6.4mg/dl,The third group: uric acid values were6.5-7.6mg/dl,The fourth group: uric acid values were7.7mg/dl or more. Multivariatebinary logistic regression was used to analyse the association between serum uric acidand CKD.Results: The prevalence of CKD in serum uric acid quartiles: firstquartile,5.3mg/dl or less; second quartile,5.4-6.4mg/dl;third quartile,6.5-7.6mg/dl;andfourth quartile,7.7mg/dl or more were18%,35%,52%and82%,respectively(P<0.05).Estimated glomerular filtration rate of the average participant had CKD and non-CKDwere53.44±7.72and81.26±12.48ml/min/1.73㎡. Compared with the first quartile ofserum uric acid, Multivariable adjusted odds for the second, third, and fourth quartile, respectively CKD were2.38(95%confidence interval(CI)1.43-3.95),4.17(95%CI,2.51-6.92),10.94(95%CI,6.62-16.08), respectively.Conclusion: High uric acid levels are independently associated with theprevalence of chronic kidney disease increases related. Increased risk of chronic kidneydisease increasing the proportion of blood uric acid levels. Therefore, Diagnosis andtreatment of hyperuricaemia early should be a important strategy to prevent CKD.