Effect Of Dexmedetomidine On Perioperative Stress Reaction In Patients Undergoing Laparoscopic Gynecologic Surgery

Objective: To investigate the effect of intravenous infusion ofdexmedetomidine on stress reaction in patients undergoing laparoscopicgynecologic surgery．Methods: Forty patients undergoing gynecological laparoscopicprocedure were randomly divded into two groups (n=20)： in group D(dexmedetomidine group),0.8μg.kg-1of dexmedetomidine was infused within10min before induction of anesthesia. And in group C (control group),thesame volume of saline was infused within10min. The levels of serum ACTH(adrenocorticotropic hormone)、 ADH(antidiuretichormone)、 Cor(cortisol)、 ALD(aldosterone)、 CA(catecholamine)weremeasured before anesthesia induction(T1), intubation(T2), skin incision(T3),introperative15min(T4)， introperative30min(T5), and postoperative1day(T6).Results: There were no significant difference in the levels of serumACTH、Cor、CA、ADH、ALD between two group sat T1、T2and T6. Whileserum ACTH、Cor、CA、ADH and ALD in Group C at T3、T4and T5weresignificantly higher than that of Group D(P＜0.05). There were no significantdifference of HR and blood pressure between two groupsat T1、T2and T6.But the change level of HR and blood pressure in Group C were statisticallydifferent at T3、 T4and T5compared with Group D (P＜0.05).Conclusion: Dexmedetomidine can inhibit the stress reaction in operation period,maintain hemodynamic stability.