Distinction Of The Functional Connectivity Between The Right Temporal Parietal Junction And The Whole Brain On Resting-state Functional Magnetic Resonance Imaging In Children With Attention-deficit/hyperactivity Disorder

Objective：To investigate the pathophysiological distinction of the functional connectivitybetween the rTPJ and the whole brain in children with Attention-Deficit/HyperactivityDisorder(ADHD) on resting-state functional magnetic resonance imaging(fMRI)andexplore the neurological mechanisms of ADHD at the point of functional connectivity.Methods：Resting-state functional magnetic resonance imaging scans were obtained in30children with ADHD from The Third Affiliated Hospital of Soochow University andanother33age and gender matched controls from a normal primary school over the sameperiod， and then，blood oxygenation level dependent(BOLD) signal was acquired tocalculate the functional connectivity of rTPJ with other brain regions． Significantdifferences of connectivity intra-class and between groups were analyzed．Also，thecorrelation between the connectivity strength and the ADHD rating scales were tested.Results：1. The pattern of functional connectivity of the rTPJ for the ADHD group wassimilar to that of the normal control group (P<0.05, corrected by AlphaSim).2. Compared to the normal controls,there were6functional connectionabnormalities in children with ADHD(revised by AlphaSim,P<0.05)，they were: leftsuperior temporal gyrus（MNI coordinate:-33、6、-48,T=4.53）、right anterior cingulatecortex （MNI coordinate:6、39、-3,T=2.97）、 right inferior parietal lobule （MNIcoordinate:42、-33、30,T=3.76）、left medial frontal gyrus（MNI coordinate:-3、63、-18,T=3.66）、right middle temporal gyrus（MNI coordinate:57、-33、-12,T=-3.64）、right cingulate gyrus（MNI coordinate:18、-21、36,T=-4.28）。3. The connection strength between the rTPJ and the whole brain showed positivecorrelation with the ADHD scores, while in normal controls, it showed negative. Theconnection strength between the rTPJ and those brain areas with significant difference wasrelevant to the ADHD scores, but they had no significant difference.Conclusions：The functional connection abnormalities between the rTPJ and the whole brain inchildren with ADHD may be relevant to the clinical symptom of attention-deficit.