| Objective Red cell distribution width (RDW) has recently been discovered to be a novel prognostic marker in patients with Coronary artery disease (CAD). The aim of this study was to determine whether an elevated RDW is associated with Framingham risk score(FRS) in patients with CAD.Methods Data was retrospectively collected from Dongyang People’s Hospital between January2012and September2013. All patients suspected coronary artery disease had received coronary angiography and their clinical data were integrated. The patients were divided into the two groups based on the results of coronary angiography (CAD group (n=283) and control group (n=109)). The Framingham risk score (FRS) was calculated for all subjects. CBC testing and biochemical measurements was performed in department of clinical laboratory medicine. All statistical calculations were performed using the SPSS for Windows. Results The mean RDW level was13.7±1.8%in the CAD group and13.1±1.0%in the control group. The mean FRS was9.0±4.9in the CAD group and6.4±3.9in the control group. RDW level and FRS was significantly higher in the CAD group compared with the control group (p=0.000). There were no significant differences among groups with respect of Hematocrit, MCV, PLT, Glucose, Urea nitrogen, Albumin, AST, TC, TG, HDL-C, LDL-C, and NT-proBNP, respectively(p>0.05). RDW level was significantly correlated with RBC (r=-0.133, P=0.029), Hemoglobin(r=-0.207, P=0.001), TG(r=0.226, P=0.000) in laboratory parameters, and FRS (r=0.206, P=0.000). In stepwise multivariate linear regression including RBC, Hemoglobin, TG, and RDW, FRS was predicted by Hemoglobin (r2=0.034, P=0.001), TG(r2=0.059, P=0.000), and RDW(r2=0.030, P=0.003).Conclusions We found a relation between higher levels of RDW and elevated FRS in patients with CAD. This finding raises the possibility that a simple marker, RDW may be associated with elevated Risk of heart events in patients with CAD. |
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