Clinical Manifestation, Tumor Markers And Radiological Characteristics Of Lung Adenocarcinomas With EGFR Mutation

ObjectiveTo study the clinical features, tumor markers and radiological characteristics of primary pulmonary adenocarcinomas with epidermal growth factor receptor (EGFR) mutation, then to analyze the correlation between EGFR mutation and clinical features, tumor markers, radiological characteristics.MethodsA total of164primary pulmonary adenocarcinoma patients who underwent a complete surgical resection at The First Affiliated Hospital, College of Medicine, Zhejiang University between March2010and May2013comprise the current study population, Mutation analysis of EGFR exon18,19,20, and21has been carried out in those patients by pyrosequencing, and the clinical data, including the serum CEA and CT imaging before the operation were available. Then analyzed clinical manifestation, tumor markers and image characteristics.ResultsThe total mutation rate of EGFR was53.0%in164lung adenocarcinoma patients, the mutation rate was64.7%in women and40.5%in men with statistical difference (P=0.002); The mutation rate in non-smokers and light smoker (smoking index<400) was61.7%and61.1%respectively, which was higher than heavy smoker (smoking index>400)(25.6%)(P<0.001); Mutation was more frequent in well-differentiated adenocarcinomas than in moderatly or poorly differentiated adenocarcinomas(P=0.039). The mutation rate in tumors containing vacuoles or cavitary lesions was higher than that in tumors excepting vacuoles or cavitary lesions (P=0.021), but which was unrelated with TNM stage, lymph node metastasis, and the serum CEA. EGFR mutation rate is unrelated with tumor diameter, GGO, spiculation, lobulation and vascular convergence sign.ConclusionEGFR mutation is more prevalent in female, non-smokers or light smokers, well-differentiated adenocarcinomas, and containing vacuoles and cavitary lesions in CT image.