The Study Of Risk Factors Of Multi Drug Resistant Tuberculosis In Urumqi

0bjective Investigation of8anti-tuberculosis drugresistance of TB in UrumqiMethods: Tuberculosis of Seven areas one county CDC in Urumqi of2011.5.1--2012.9.30,specimens were cultured with improved L-J medium, culturepositive isolates using the Drug sensitive test of8anti-tuberculosis drugs: INH、RFP、EMB、SM、OFX、KM、AK and CPM．And make statistical analysis of the drug resistance.Results:259drug sensitive test were done in pulmonary tuberculosis patient， drugresistant pulmonary tuberculosis with71cases，Total drug resistance rate was27.4%,multiple drug resistance rate of7.72%,extensively drug resistance rate of3.09%. TheInitial treatment and retreatment resistance rates were26.4%and37.5%, multi-drugresistant rate of5.96%and25%, respectively. Drug resistance to order:INH>SM>RFB>EMB。 Resistance of8anti-tuberculosis drugs were as follows：INH>SM>OFX>RFB>EMB>AK>CPM>K。 Male154cases, female105cases, Totaldrug resistance rate were29.2%and24.8%;Age distribution between the age of14-86years old, average age was40.8years old. The age group≤18years of resistance rate of21.1%,19-59years old resistance rate of29.7%,21.8%resistance rate≥60agegroup;The ethnic distribution: Han resistance rate of25.5%, the Uighur resistance rateof34.2%, Hui resistance rate of18.2%; Gender,Age, National resistance rates bystatistical analysis, the difference was not statistically significant (P>0.05). With182cases of local patients and77cases of nonlocal patients, total drug resistance rate were29.7%and22.1%. The first-line anti-TB drug resistance rates were25.8%and15.6%,respectively. Seven districts and one county resistance rates between20%-40%,multi-drug resistant rate between0%-10%. Drug resistance of Mycobacterium in Gender,Age and Nation were independent in Urumqi. But multi-drug resistant rate related to thetreatment. Retreatment patients were larger than the initial treatment. Resistance rate ofthe local、field and Seven districts and one county rates of multidrug-resistant differencewas not statistically significant (P>0.05). Multi-drug resistant rate is closely related tothe treatment of history. The logistic multifactor analysis is p=0.002， OR=8.997。 Conclusion: To implement effective treatment and management of patients withpulmonary tuberculosis, to ensure that patients can regular treatment; Drug sensitive testto do as much as possible to retreatment patients and make individualized treatmentbased on Drug sensitive test results.