Clinical Analysis Of51Young Patients With Endometrial Carcinoma (EC)

Objective：To investigate the clinical characteristics and the pathological features of patientswith endometrial cancer, and to investigate the association between the features and theprognosis of the patients. And then try to through multi-disciplinary collaboration toprovide more individualized treatment to the young patients with endometrial cancer.Methods：A survival analysis of51young patients (≤40years old) with endometrial cancerduring2008-2012is reported. Survival analysis was carried out using the Kaplan-Meiermethod. The difference between survival curves was analyzed by the log-rank test. Coxregression model was informed in multi-variable analysis. Probability values of0.05orless were considered.Results:1.88.2%cases of endometrioid carcinomas;68.6%G1and G2;60.8%no and≤1/2myometrial invasion;86.3%PR-positive,90.9%ER-positive.2. Different surgical-pathological stage make a different survival curve, and therelative risk (RR) is3.32. each additional clinical stage, the risk of death in patients withan increasing, at3.32times.3. Retain ovary or not make a different survival curve, and the relative risk (RR) is2.185.4. Ascites cytology positive are risk factors for lymph node metastasis（P＜0.05）.5. No significant relation between the degree of tumor differentiation or postoperativechemotherapy and five year survival rate after operation was noted in the patients（P>0.05）.Conclusions: 1. The surgical-pathological stage plays the most important roles in the prognosis ofyoung patients with endometrial cancer. Early diagnosis and treatment ofendometrial cancer is important.2. Positive peritoneal cytology is a risk factor for lymph node metastasis, suggestingthat peritoneal cytology examination is still of certain value.3. For the patients with endometrial cancer of stage IA, and with good reaction tohormone treatment, surgery can be postponed with closely monitoring for a chanceof pregnancy.4. To remain ovary(s) appropriately in the radical correction for the young patientswith endometrial cancer must be fully assessed before surgery.5. Hormone replacement therapy (HRT) could be used in the patients afterhysterectomy and double ophorectomy and without high risk factors (early,well-differentiated, myometrial invasion <1/3, estrogen receptor and ascites fluidwere negative). Non-hormonal preparations to relieve the symptoms of artificialmenopause are optional.6. Postoperative adjuvant chemotherapy does not improve the survival rate of thepatients, prevention of over-treatment.