Correlation Study Between Smoking And Obstructive Sleep Apnea And Hypone A Syndrome

Objective To explore the correlation between smoking habits and obstructive sleep apnea and hyponea syndrome (OSAHS).Methods Data were collected from the chart review of sleep disorders or sleep-breathing disorders patients who had been undergone overnight Polysomnograpghy (PSG) at Sleep-Disordered Breathing Center of Guangxi from1th July2009to30th June2012. Smoking history were quantified by using retrospective questionnaires. Patients diagnosed as having OSAHS were defined by an apnea-hypopnea index(AHI)(events/h) of greater than15events per hour. Patients with AHI (events/h) between5and15were ruled out from this study. Patients without OSAHS were defined by an AHI (events/h) less than five events per hour. The association of smoking status and smoking severity with OSAHS was analyzed. Results A total of903patients were excluded from2243patients. OSAHS group contained929patients and non-OSAHS group contained411patients. Smoking prevalence in OSAHS group was47.1%and in non-OSAHS gruop was25.5%. Logistic regression analyses were performed to investigate the effects of smoking habits while adjusting for age, gender, body mass index (BMI), and drinking history. Current smokers were found to be1.446times more likely to have OSAHS than never smokers (95%CI:1.079-1.939, P=0.013). Current smokers with pack-years≥30were more2.382times more likely to have OSAHS than never smokers to have OSAHS (95%CI:1.127-4.375, P=0.012). Current smokers diagnosed as having OSAHS with pack-years>30had more percentage of total sleep time (TST) spent with saturation of oxyhemoglobin (SaO2)<90%((20.5±23.1)%vs (15.6±18.8)%, P=0.004) and lower average SaO2((69.4±10.3)%vs (73.2±9.7)%, P=0.000) during sleep than never smokers diagnosed as having OSAHS. Current smokers diagnosed as having OSAHS with pack-years≥30were1.893times more likely to spend more than5%of TST at SaO2<90%than never smokers diagnosed as having OSAHS (95%CI:1.046-3.423, P=0.035)Conclusions Smoking is associated with significant increased risk of OSAHS and nocturnal hypoxia in current smokers, especially in current smokers with≥30pack-years. Smoking can exacerbate nocturnal hypoxia in OSAHS patients.