| Background and objective tumor-stroma ratio (TSR) have been proved to be a new and reliable independent prognostic factor in some solid tumors.The aim of the study is to test the different expression of TSR and its prognostic significance in Gastric cancer.Methods A total of64patients who underwent surgery resection for Gastric cancer were included in this study. TSR was assessed visually on the hematoxylin-stained tissue sections of surgical specimens. Patients with more than50%intratumor stroma were quantified as the stroma-rich group and those with less than50%as the stroma-poor group. Follow-up of two groups of patients’ overall survival.Results In64cases of tissue samples,48cases were included in the stroma-poor group, while16cases in stroma-rich group. the proportion were75%,25%. The different expression of TSR in gastric cancer tissue was not correlated with gender, age and differentiation grade, pTNM staging, and so on. Kaplan-Meier survival analysis showed that the different expression of TSR was significantly correlated with survival days (P=0.026). Cox regression analysis showed that different expression of TSR is a independent prognostic factor for gastric cancer (HR=1.273,95%CI:1.017-2.334)Conclusion TSR is one of the factors affecting the prognosis of gastric cancer. |
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