An Experiment Study Of Transcatheter Implantation Of Anew Expandable Aortic Filter In In Vitrio Dog

ObjectiveTo design a new expandable aortic filter and to evaluate the feasibility and filterretrieval of transcatheter implantation of the filter and effectiveness of capturing thethrombus in vitro dog aorta.Materials and MethodsA total of five in vitro dogs’ hearts with ascending aorta, arch, descending aorta,brachiocephalic artery, left carotid artery, subclavain artery were anatomed and theangiography was performed in the five aortas to obtain the diameters and length of thedifferent aorta.A new expandable aortic filter was developed based on the diameters and length ofthe dogs’ aorta. The aortic filter implantations were performed by inferior vana cave filterdeliver system (6F). The filter was loaded into the sheath. The delivery catheter was thenintroduced through the guide wire into the aorta under fluoroscopic guidance. After correctposition was confirmed by fluorography, the new expandable aortic filter was thenadvanced retrogradely to the in vitro ascending aorta, the aortic arch and descending aortain dogs. The immediate results of implanted aortic filter were evaluated with angiographyto confirm filter position.ResultsNormal aorta size of in vitro dog(weight22±2.8kg) is as follows: Length ofascending aorta:2.682±2.4cm,width of ascending aorta:0.955±0.2cm. Length of aorticarch:2.285±1.3cm, width of aortic arch:0.981±0.2cm. Length of descending aorta:4.818±4.6cm, width of descending aorta:1.076±0.3cm.Our new expandable aortic filter is composed of a metal-mesh framework and filter,which structure is something like a inferior vena cava. The length of this filter is2.3mmand the width of this filter is1.5mm.The shape of the filter mesh is diamond, and thelength of the mesh is0.7mm and the width of mesh is0.5mm. Five devices were successfully implanted into aortic position of the in vitro dogs’aorta and immediate observation after procedure by angiography showed that the aorticfilters were in the desired position after implantation.This filter can capture0.3mm,0.5mm.0,6mm thrombus in diameters, however,0.1mm and0.2mm thromboses in size could not be captured by the filters.ConclusionsThis preliminary study indicates that the procedure of transcatheter aortic filterimplantation with our new expandable aortic filter is feasible, retrieved in vitro dogs’aortas and effective for capturing over3mm thrombus.