The Association Between Glucose Tolerance Status, Different Obese Indexes And Arterial Stiffness In Beijing’s Community Populations

ObjectiveTo study characteristics of the arterial stiffness in different glucose tolerance status,to analyze the association between glucose tolerance status, obese indexes and arterialstiffness separately, and to explore the risk factors of arterial stiffness in Beijingcommunity population.MethodsPeople from two communities of ShiJingShan district in Beijing, aged40years orolder, underwent examinations of questionnaire interview, anthropometricmeasurements(height,weight,BMI,WC,HC,WHR,WHtR), biochemical indexes,HbA1cevaluation,75gOGTT,ankle-brachial index(ABI) and brachial-ankle pulse wavevelocity(baPWV) measurement,9185cases were enrolled and categorized into6groupsbased on the results of OGTT (diagnosed standards of2013ADA Commentary on theDiagnosis of Diabetes Mellitus)and diabetes history: normal glucose tolerance(NGT)，impaired fasting glucose (IFG), impaired glucose tolerance(IGT), IFG+IGT, newlydiagnosed DM (NDM) and diagnosed DM(DDM).Results1. baPWV increased gradually from NGT to DDM group （1528±308）cm/s,(1625±370)cm/s,(1644±351)cm/s,(1747±485)cm/s,1799±485cm/s,(1841±456)cm/s,P<0.001）. Except for between IFG and IGT group, there were statistically significantdifferences in baPWV between any other two groups(P<0.05）.After adjusting forconfounding factors such as age, sex, BMI, there was significant difference among thesix groups [(1612.0±5.8)cm/s,(1643.0±7.7)cm/s,(1639.0±12.6)cm/s,(1690.0±9.3)cm/s,(1719.0±9.6)cm/s,(1725.0±9.3)cm/s,P<0.001].2. According to the standards of BMI, There was statistically significant differences in normol,overweigt and obesity group [(1613±384)cm/s,(1664±407)cm/s,(1697±400)cm/s,P<0.05)].According to the criterion of WC,WHR and WHtR, baPWVof central obesity group was significantly higher than the normal group[WC (1693±408)cm/s,(1625±390)cm/s;WHR（1690±399)cm/s,(1575±391)cm/s; WHtR(1718±422)cm/s,(1574±350)cm/s,P<0.01].After adjusting for age, gender and cardiovascular risk factors,the multiple regression analysis found that for every0.1point increase in WHR andWHtR, the PWV increased40.6cm/s and55.3cm/s, respectively.3. According to the criterion of WC,WHR and WHtR, baPWV of central obesitygroup was significantly higher than the normal group in NGT,IGR,DM group,respectively（P<0.05）.There was no statistically significant differences based on BMI inDM group, expect NGT and IGR group. Central obese indexes(WC、WHR、WHtR)showed a positive correlation to PWV in the studied groups. BMI was only positivelycorrelated with baPWV in NGT group, there was no significant correlation in IGR andDM group.4. baPWV was significantly positively correlated with age, smoking, BMI, WC,SBP, PP, HR, Cr, TG, TC, LDL-C, and was negatively correlated with HDL-C. FPG,2hPG and HbA1clevels independently associated with baPWV(r=0.227,0.279�'�0.267，P<0.05). Multivariate linear regression analysis showed that age, hypertension, PP, TG,HR, WC,WHR,WHtR,FPG,2hPG, HbA1cwere independently risk factors of baPWV.ConclusionsThe increasingly deranged glucose homeostasis was associated with increasedarterial stiffness in community population. central obesity indicators (WC, WHR, WHtR)were independent risk factors of arterial stiffness.The measures of central obesity (WHRand WHtR) correlated better than BMI with arterial stiffness. It was significant forguarding against cardiovascular and cerebrovascular events by detecting the abnormalglucose tolerance and controlling the degree of central obesity, assessing andintervening the arteries stiffness early.