168Strains Of Clinical Distirbution And Drug Resistance Of Acinetobacter Barman Strains Source Analysis

Background: In recent years, bacterial drug resistance problemshave attracted the attention of more and more medical professionals.When patients get infected by resistant strains, it will not only extend thelength of cure time, but increase the economic burden and even lifethreatening. Acinetobacter is a kind of conditional pathogenic bacteria,whose infection rate presents a rising trend year by year, the people’semphasis on it enhances unceasingly. In the case that a broad spectrum ofantimicrobial agents are widely used, the number of multipledrug-resistant acinetobacter increase year by year. The antimicrobialagents which you can use now were no use to solve drug-resistant strains,and acinetobacter easily diffuses in the form of cross infection in thehospital, which increase the difficulty of hospital anti-infective treatment.Among a lot of acinetobacter, Acinetobacter Baumann is the highestpercentages of strains and is hardest to apply pharmacy. In addition, thedrug resistance of acinetobacter spectrum performances differently indifferent countries, regions, and even different departments in a hospital.In terms of comprehensive hospital infection, the study of acinetobacterlasts for a long time. This article’s analysis will be based on the Jilinprovince people’s hospital clinical infection of acinetobacter Baumann,and the article will explore the nosocomial infection source of resistantstrains.Objective: Analyze in Jilin province people’s hospital on the conditions of acinetobacter baumannii and sources of drug resistantstrains, in order to explore its resistant mechanism and put forwardcorresponding measures,then to provide the reference to control of theacinetobacter baumannii clinical infection in Jilin province people’shospital. The research object of this paper is the Jilin province people’shospital,and though the method of observational studies, we review t thedrug resistance of acinetobacter baumannii and separation condition ofsystematic of Jilin province people’s hospital on January1,2010-December31,2013. The investigation contents include the separation ofacinetobacter, Acinetobacter Baumann coli resistance analysis, pathogendistribution, etc., and then make statistical analysis.Results: In four years (January1,2010-December31,2013) wehave detected at least500cases of acinetobacter. Among them,we detectthe40cases of acinetobacte in2010, which accounts for1.56%in theannual inspection to the total number of bacteria; and we measure40cases of acinetobacter, accounting for1.56%of the annual inspection tothe total number of bacteria; then we check measure80cases, accountingfor3.2%of the annual inspection to the total number of bacteria; in2013we check and measure340cases, accounting for12.74%of the annualinspection to the total number of bacteria; In2012and2013,casesincreased significantly (P <0.05);There are156cases of drug resistance,except for add ring element and polymeric. On January1,2012-March1,2014, the detection of acinetobacter baumannii count96cases, occupying (168cases)57.14%in the same period acinetobacter detection.,whichincreased significantly (P <0.05)in2013contrast to2012. In theseparation of specimens of acinetobacter baumannii, the sputumspecimens of47cases (48.96%), pharyngeal swab25cases (26.04%),urine specimens of7cases (7.29%), pus16cases (16.67%), oral ulcerswab in1case (1.04%). The analysis of the drug resistance ofacinetobacter baumannii suggests that its resistant rate on cefalotin canreach100%; With nitrofurantoin for the resistant rate of91.42%, andcefoxitin and ampicillin resistant rate of87.21%, acid in bar/amoxicillinresistant rate of46.02%, can achieve less than15%of resistance to theantibiotics. In2013appeared in3patients with multiple drug resistanceof acinetobacter baumannii. In2012and2013acinetobacter baumannii ofcompound new Ming, amoxicillin/rods acid, with nitrofurantoinWestwood, nai for m star because, ammonia, cefotaxime, cefazolin heorganism, the resistance of cephalosporins west hall did not changesignificantly (P>0.05), the gentamycin, imine south, nalidixic acid andfluorine of sand culture, shilling for card, and the drug resistance oftobramycin rose,2013data were18.3%,3.1%,16.2%,9.3%,16.2%and10.4%. Granulocytopenia in symptoms of infection, patients with a totalof5cases, a total of3cases of leukaemia patients, immunodeficiencysyndrome patients occurred in1case;8patients who use adrenal corticalhormone,10patients who use breathing machine,46patients usesurgical treatment to adopt the indwelling catheters.Conclusion:(1) The infection rate of acinetobacter of hospitalized patients in Jilin area increases, especially the prevalence of acinetobacterbaumannii.(2)Under the background of rising acinetobacter baumannii,patients still have higher sensitivity to h amino sugar two classes, thethird generation cephalosporins, hydrocarbon alkene, mildew inhibitorssuch as antibiotics,.(3)Among the hospitalized patients in Jilin people’shospital, acinetobacte has multiple drug resistance, especially to carbonblack mildew resistant strains, which need a lot of attentions.(4) Thepatients who have damage to the immune function and accepted theinvasive treatment should raise awareness of acinetobacter baumanniiinfection.(5) To properly use carbon penicillium alkene and thirdgeneration cephalosporins broad-spectrum antibiotics can control thegeneration of multiple drug-resistant strains of acinetobacter baumannii.All in all, acinetobacter baumannii belongs to the conditional pathogenicbacteria, whose infection rate increases. We can reduce the occurrence ofinfection and drug resistance by the rational use of drugs in clinicaltreatment.