Therapeutic Efficacy And Prognosis Factors Analysis Of Cushing’s Disease Undergoing Minimally Invasive Surgery

Objective: To investigate the therapeutic effect of Cushing’sDisease after microsurgery treatment and analyze the correlativeprognosis factors.Methods: A retrospective analysis was carried out which used theclinical records of24Cushing’s Disease patients undergoingmicrosurgery treatment. All the patients had been treated in Firstdepartment of neurosurgery, China-Japan Union Hospital of JilinUniversity between March,2011and May,2014. According topreoperative ACTH levels, tumor size, invasion, sex, pathologicaldiagnosis, surgical method etc, the patients were classified into differentgroups. The clinical symptoms, ACTH level and imaging examinationwhich were followed up were used to evaluate the therapeutic efficacyafter microsurgery treatment. We used the statistical methods to analyzedthe data, and analyze the correlative prognosis factors of microsurgerytreatment of Cushing’s Disease.Result: Total remission rate is75.00%. The male is70.00%and thefemale is78.60%, but it is not statistically significant. The remission rateof microadenomas, macroadenomas and giant adenomas respectively are100%,61.54%and50.00%. The remission rates of invasive pituitaryadenomas and non-invasive pituitary adenomas are statisticallysignificant, respectively are50.00%and92.86%. The differences are notsignificant in the preoperative ACTH levels group, surgical method groups and pathological diagnosis groups.Conclusion: Surgery is the first choice for Cushing’s Diseasetreatment, microsurgery applies to the overwhelming majority ofCushing’s Disease cases. The remission rate of Cushing’s Diseasepatients after microsurgery is related to the size and invasiveness ofpituitary adenomas, but not related to sex, preoperative ACTH levels,surgical methods and pathological diagnosis. The size and invasivenessof pituitary adenomas are the risk factors to the prognosis of theCushing’s Disease patients after microsurgery.