58Cases Of Primary Sj(o|")gren’s Syndrome Clinical Features Analysise

Objective：Through retrospective analysis the clinical manifestation, auxiliary examina-tion, clinical data of primary Sjo gren’s syndrome (primary Sjo gren’s syndrome,pSS), summarize the clinical characteristics of primary Sjo gren’s syndrome, i-mprove the diagnostic level of primary Sjo gren’s syndrome.Methods：We select the general information, clinical manifestation, laboratory exami-nation, imaging and other tests of58patients who were diagnosed with pSSin the Second Hospital of Jilin University during December2009-January2014,and by the application of statistical methods to analyze the epidemiology, clini-cal characteristics and the link.Results：3male cases and55female cases in all patients, male to female ratio is1:18.33; the age ranged from18to79years old, the average age was53.57±13.96years old; the clinical manifestations were varied, the common symptoms:xerostomia35cases (60.34%), dry eyes31cases (53.45%), joint pain21cases(36.21%), cough20cases (34.48%), dyspnea20cases (34.48%); regular labora-tory examination of abnormal mainly for: anemia28cases (48.28%), elevated s-erum immunoglobulin23cases (39.66%), proteinuria23cases (39.66%), Aspar-tate aminotransferase (AST) increased18cases (31.03%); Abnormal cases ofimmunological examination are respectively: anti-SSA antibody positive57cas-es (98.28%), ANA screening positive54cases (93.10%),52kDa protein antib-ody45cases (77.59%),erythrocyte sedimentationrate (ESR) faster37cases (63.79%), anti-SSB antibody positive29cases (50.00%), anti-SSA antibodyand an -ti-SSB antibody positive29cases (50.00%), rheumatoid factor (RF) positive29cases (50.00%); lung CT examination showed mainly as follows: the interstit-ial pneumonia18cases(31.03%), pleural thickening16cases (27.59%), pleuraleffusion9cases (15.52%), pulmonary bulla3cases (5.17%); additional exami-nation:24cases of patients with filter paper test and corneal staining, the pos-itive were23cases,22cases,17cases of labial salivary gland biopsy for all.3patients underwent salivary gland scintigraphy,2cases of them with Sj(o|¨) gren’s syndrome; The patients with kidney damage according to the laboratory examin-ations showed37cases (63.79%), of which7patients underwent renal biopsyand pathological diagnosis were three cases of membranous nephropathy,1caseof IgA nephropathy with renal arterioscleros, two cases of chronic tubulointerst-itial lesions, glomerular minor lesion in1case. Clinical data analysis betweendifferent ages: cough, aspertate aminotransferase elevated, CRP elevated were m-ore in elderly patients; RF higher, C4decline were more in youth patients; t-he relationship between different immunological antibodies and clinical data: an-ti-SSB antibody positive easily show globulin increases, thrombocytopenia;52kDa protein antibody positive easily characterized by dry mouth, joint pain, an-emia, elevated serum immunoglobulin; anti-SSA antibody positive merger52k-Da protein antibody positive easily characterized by higher RF, anti-SSA antib-ody positive merge52kDa protein antibody negative easily characterized by c-oughing, dyspnea, interstitial pneumonia. Relationship between different immun-ological antibody: anti-SSA antibody positive and anti-SSB antibody positive o-ften merge52kDa protein antibody positive.Conclusion：1. Primary Sj(o|¨) gren’s syndrome is mainly common in women and the prev-alence is in the elderly age-based.2. Xerostomia, dry eye were the most rare In Clinical manifestations; ane-mia, globulin increased anti-SSA antibody positive, ANA screening positive we- remore obviously in laboratory tests; filter paper test, corneal staining and llab-ialsalivary gland biopsy positive rate were higher in the other tests.3. Cough, elevated aspertate aminotransferase, elevated CRP were more inelderly patients, higher RF, C4decline were more in young patients.4. The anti-SSA antibody and anti-SSB antibody positive often merge52kDa protein antibody positive; xerostomia, joint pain, anemia, elevated globuli-n, RF higher common in52kDa protein antibody positive patients, respiratory-system performance such as interstitial pneumonia common in52kDa proteinantibody positive patients. Globulin increased and thrombocytopenia common inSSB antibody positive patients.