The Analysis Of The Serum Level Of Six Kinds Of Elements And Characteristics Of All Ages In Children

Object Trace elements (Iron, zinc, copper) and macro elements(magnesium, calcium, phosphate) are important material for human body, andmaintain the normal activity and metabolism of the human body. They play animportant role on human health. These elements, are not only involved in celldivision, formation of nucleic acid，but also have influence on endocrine andimmune system of human body. The concentration of these elements have anormal range, it will cause body disorders when any kind of elements isinsufficiently or excessively ingested. Children are in a crucial period of growthof development, the development of digestive is still immature, the secretion ofgastric acid and digestive enzymes are less, and enzyme activity is lower.Meanwhile, children are prone to disorders of digestion. All above can affect theabsorption of nutrient and lead to the imbalance of these elements. Due to theinteraction of elements, the imbalance of one kind of elements can influenceother elements. In this paper we test the levels of iron, magnesium, zinc, copper, calcium and phosphate in different period of children, and study the interactionof elements. At last, the results o f the paper can offer basis for the treatment andprevention of disease which caused by the disorders of elements.MethodsIn the study, we retrospectively analyzed1040children between infant and16years old from Jan2014to Dec2014in The First Hospital of Jilin University.Children were divided into5groups, namely the infant group (128boys,72girls), children group (108boys,92girls), preschool group (140boys,100girls),the school-age group (132boys,68girls), and adolescence group (112boys,88girls). Apart from the preschool group had240children, each of the rest grouphad200children.2ml venous blood were collected in all children. Theconcentrations of serum iron, magnesium, zinc, copper, calcium and phosphatewere tested by Automatic biochemical analyzer (Hitachi7600-210). Data wereperformed with SPSS21.0statistical software (SPSS). The level of each elementwas in accordance with normal distribution. Measurement data of serum iron,magnesium, zinc, copper, calcium and phosphate were reported by mean andstandard deviation. Due to heterogeneity of variance, we compared the levels ofelements in different periods by rank sum test, P<0.005means that thedifference was statistically significant. Pearson method was used for correlationanalysis of elements, P＜0.05means that the difference was statisticallysignificant. Result(1)Apart from the level of serum zinc was lower than the normal range, thelevels of other elements in different ages were in the normal range. Theconcentrations of serum iron, serum magnesium, serum zinc in infant groupwere obviously less than the elder. The concentrations of serum iron and zinc inchildren group were obviously less than school-age group and adolescencegroup. But the concentration of copper in children group was higher thanschool-age group and adolescence group. At last, the concentration of serumiron in pre-school group was lower than school-age group and adolescencegroup.(2)The results of correlation analysis: The levels of serum iron and serumzinc were positively correlated (r=0.366, P <0.001). The levels of serum ironand serum copper were negatively correlated (r=-0.275, P <0.001). The levelsof serum zinc and serum copper were negatively correlated (r=-0.162, P=0.009). The levels of serum zinc and serum calcium were positively correlated (r=0.156, P=0.012). The levels of serum calcium and serum phosphate werenegatively correlated (r=-0.256, P <0.001). Other elements had no significantcorrelation.Conclusion(1) Children who lack of a certain element needed additional supplementbesides the diet.(2) The result of the paper indicated that infants were lack of zinc, and thelevels of iron and magnesium were lower than the older.Therefore the infants needed to supplement zinc and strengthen the intake and balance of iron,magnesium from the diet.Young children were lack of zinc, and the level of ironwas lower than the older. So the young children needed to supplement zinc andstrengthen the intake and balance of iron from the diet.Meanwhile,the preschoolchildren needed to pay attention to the intake and balance of iron from the iron.(3) Due to the interaction of elements, the intake dosage of a certainelement should be proper, and we needed to pay attention to the ratio andbalance of elements when we needed to supplement two or more kinds ofelements.