Efficacy Studies Of Jipi Huatan Decoction In The Treatment Of Phlegm Syndrome Of Obstructive Sleep Apnea Hypopnea Syndrome

Reserch background:Obstructive sleep apnea hypopnea syndrome (OSAHS) is a self-eighties of last century began to pay attention respiratory disease, its prevalence is rising, potentially dangerous, more and more attention of scholars at home and abroad.Sleep airway soft tissue, muscle and nerve can collapse increased,body fluids, endocrine factors for its pathogenesis.Chinese Society of Respiratory Diseases, will recommend OSAHS treatment with positive airway pressure, oral orthodontic and surgical treatment, although can relieve symptoms and improve quality of life, but positive pressure ventilation expensive, high-risk surgery, topical remission, relapse may exist, the limitations of these treatments, seriously affecting the compliance and clinical efficacy in the treatment of patients with OSAHS.OSAHS belongs Chinese medicine " snoring ", the fundamental reason is that endogenous phlegm, throat orifices negative, airflow obstruction, snoring occurs constantly, rather then involving internal organs, but changed his birth disease.Its pathological nature is false is mixed, mainly real evil, based on an analysis of previous treatment of clinical cases that the disease syndrome characterized mainly with phlegm Jipi huatan decoction is the treatment of OSAHS mentor experience side by WendanTang and ZhizhuPill using in patients with good compliance, can alleviate clinical symptoms to some extent.Objective:In this study, a randomized control study, observed before and after treatment of OSAHS Spleen phlegm main square syndromes (snoring, stop snoring/apnea, daytime sleepiness), sleep apnea hypopnea index (AHI), the longest apnea time oxygen desaturation index (4%ODI), the lowest oxygen saturation (LSaO2), changes in BMI, and preliminary evaluation of clinical efficacy in the treatment of OSAHS spleen side of phlegm.Method:Using simple random method, using a random number table, line26,34and35as the starting, the provisions for the control group, the odd, even for the observation group. The control group received life management, temperance, diet control, adequate exercise guidance, for12weeks.On the basis of the observation group life management of the control group given oral Spleen side, one dose a day, morning and evening hours, for12weeks.Recorded before and after treatment of traditional Chinese medicine syndrome (snoring, stop snoring/apnea, daytime sleepiness), sleep apnea hypopnea index (AHI), the longest apnea, oxygen desaturation index (4％ODI), the lowest oxygen saturation (LSaO2), BMI index is calculated using statistical software SPSS17.0for statistical analysis.Result:1、 The study included from November2012to November2013Respiratory outpatient treatment at Wangjing Hospital, China Academy of Traditional cases met the inclusion criteria of the60cases,30cases in which the observation group,30cases in the control group.Before treatment, TCM syndrome score (snoring, stop snoring/apnea, daytime sleepiness), BMI, sleep-disordered breathing index, the longest apnea, oxygen desaturation index, minimum oxygen saturation difference was not statistically significant, comparable.2、 After treatment, TCM symptom scores compared with before treatment were improved, the difference was statistically significant; difference between the two groups of patients before and after treatment syndromes integral observation group decreased symptom score higher, a statistically significant difference; before and after treatment rate between TCM syndromes, the observation group was significantly higher, the difference was statistically significant; describes the general life coaching can improve clinical symptoms, combindeing Jianpi Huatan Decoction effect more good.3、 AHI before and after treatment were decreased significantly; AHI difference between the two groups of patients before and after treatment, the difference was statistically significant. Description guidance can improve the general living conditions of apnea, and Jianpi Huatan Decoction can enhance its efficacy. 4、 Before and after treatment were shortened longest apnea time, the difference was statistically significant; before and after treatment the longest apnea time difference, the difference was not statistically significant. Describes the general life guidance or comdineding Jianpi Huatan Decoction is no significant difference in terms of shortening the longest apnea time.5、Two groups of patients before and after treatment decreased4%ODI, the difference was statistically significant; before and after treatment4%ODI difference,the difference was significant statistically significant.4%ODI reflects the oxygen damage, represents the decreased saturation of blood oxygen level changes during sleep, Description of the general life guidance combined with Jianpi Huatan Decoction can significantly reduce the oxygen reduction event.6、before and after treatment, LSaO2were up, the difference was statistically significant; before and after treatment LSaO2difference, the difference was not statistically significant. Description The general life guidancecan can improve hypoxia, Combined effect of Jianpi Huatan Decoction did not increased obviously.7、 BMI before and after treatment were decreased significantly; BMI difference between the two groups of patients before and after treatment, the difference was not statistically significant. General life guidance reduce obesity, joint Jianpi Huatan Decoction increase its role no.8、 Course of treatment, the observation group patients without rash、drug eruption and other allergic reactions; no nausea、 stomach discomfort、 diarrhea and other adverse reactions. Description Jianpi Huatan Decoction security acceptable, no significant adverse reactions.Conclusion：Through this study proved Jianpi Huatan Decoction can reduce sleep disturbance index, oxygen desaturation index, to a certain extent, to shorten the longest apnea time, increasing the minimum oxygen saturation, thereby improving sleep hypoxemia, improve obstructive sleep apnea symptoms.Results from this study can also be seen:the observation group snoring, stop snoring/apnea, daytime sleepiness symptoms were relieved after treatment observation group TCM syndrome score improvement and TCM syndrome was significantly higher, shows the overall concept of traditional Chinese medicine and syndrome differentiation and treatment.