The Pharmaceutical Research Of Kangguzengzhiteng Tablets

Kangguzengzhiteng Tablets consist of Radix Astragali、Radix Angelicae sisensis and many other herbs,it was used in the clinical years under the guidance of the theory of Chinese medicine-based Chinese herbal compound decoction,it has a good effect treating leucocyte decrease what chemotherapy leads to according to clinical experimentation.The TCM formula is better combining the theory of TCM and the modern research and clinical experience into one. According to the needs of modern medication,the subject of the theory of Chinese medicine under the guidance of the prototype decoction converted into tablets, the tablets used in the preparation process,quality standards and stability before the clinical pharmacy was investigated experimentally.In the study of the preparation process,according to the indication function of prescription and the physicochemical property of each drug’s effective components,the single factor and orthogonal test used to optimization of the water extraction process of Astragali radix、Epicedium radix and rubra and Spatholobus radix and rubra.Plus ten times the amount of water,soaked two hours,extracted one hour,plus eight times the amount of water,extracted one hour one time.The Astragaloside,Ferulic Acid and dry extract yield as the index.The optimum alcohol extraction process of Angelicae sisensis radix and ynariafortunei radix and rubra were determined by single factor test and orthogonal test,Plus eight times the amount of80%alcohol,extracted one hour,plus six times the amount of80%alcohol,extracted one hour one time.The Astragaloside, Ferulic Acid and dry extract yield as the index.The water extract liquid was respective purified impurity,by vacuum concentration,purification liquid and concentrated liquid taken sponging drying,made into extract powder.The Colla Corii Asini in the prescription into fine powder and mixed extract powder;By the single factor testoptimized the first-rank type and ration of accessories,mixed drug powder and accessories,used by granulating,namely.In the study of the quality standards,the TLC was used to identify Astragali radix. Angelicae sisensis radix, Epimedium herb, Colla Corii Asini in the prescription,the chromatographic spots were clear,good repeatability,no negative interference;Used HPLC to determined the effective components of the monarch drug Astragali radix and Angelicae sisensis radix,astragaloside,ferulic Acid and take methodology research.Tentatively the astragaloside content shall not be less than0.199mg/pian,the ferulic Acid shall not be less than0.162mg/pian.In the study of the stability test, adopt accelerating test and long term test investigated the stability of the Kangguzengzhiteng Tablets, indicating that the preparations in clinical drug packaging,drug properties and stability in the eighteen months.