The Magnetic Resonance Imaging Study On Cerebral Cingulate And Amygdala In Patients With Major Depressive Disorder

Objective: Using MRI (magnetic resonance imaging, MRI) technology through betweenthe first episode, untreated depression and normal weight control group structural MRIbrain scans, using voxel-based morphology assay (the VBM) of the brains of patientswith major depressive disorder cingulate and amygdala volumes exceptions study toinvestigate a possible major depression neuroimaging indicators of depression may thusspeculate pathophysiology, clinical diagnosis and assessment treatment provides a newreference, providing a scientific basis for more effective assessment and prevention ofdepression.Research Methods: American Diagnostic and Statistical Manual of mental disorders(Diagnostic and statistical manual, fourth edition, DSM-Ⅳ) diagnostic criteria for majordepressive disorder enrolled patients, requiring patients HAMD score≥24points and thehealthy control group <7points,10cases of serious episode of depression, and10age-and sex-matched normal control group MRI brain structure, conduct a head MRI scan.Voxel-based morphological assay (voxel-based morphometry, VBM) of brain structure inpatients with major depression were analyzed,Results:10cases of major depression patients and10cases of healthy control werecompleted appropriate clinical data collection and MRI scans. The results showed that: 1.There was no gender and age composition in terms of significant differences;depression years of education for the group (12.40±2.36), the healthy control group(13.40±2.32), the two groups had no significant difference; depression group HAMDscore (38.80±2.15) points healthy control group (3.70±1.45) points, there was asignificant difference between the two groups.2. By MRI scans, the data processinganalysis and comparison of major depression patients and healthy controls found that thefirst onset, untreated cingulate cortex and right amygdala gray matter volume in the fronton both sides of major depression in patients with significant reduced.Conclusion: Cingulate cortex and the amygdala, the brain’s gray matter volume changesin patients with major depression before the brain, mainly for the front sides of thecingulate gyrus and right amygdala significantly reduced gray matter volume. Multiplebrain regions of abnormal depression group structure, especially the first two sidescingulate cortex and right amygdala abnormal brain structure and function, which may beone reason major depression pathophysiological mechanisms.