| Background and purpose:All around the world, breast cancer is the first leading type of all cancers and the fifth leading causes of death in all types of cancers in female. Tumor size, regional lymph node metastasis, distant metastasis, TNM stage and tumor characteristics are important prognosis factors in breast cancer. In the current study, we aim to study prognosis effects of above factors in Eastern China.Method:We conducted a retrospective analysis of breast cancer patients managed at the Second Affiliated Hospital of Zhejiang University between1January2000to1December2009. Univariate analysis was used to determine the prognosis effects of above factors in these patients.Results:1205newly diagnosed breast cancer patients were followed up. Ages at diagnosis range from16to96years old, median51years old. The age peak ranges from45-54years old. Univariate analysis revealed age, family history, early menarche, late menopause, breast-feeding history and parity were not prognosis factors in breast cancer. Increasing patients got recurrence and metastasis with the increase of tumor size or regional lymph node metastasis. Tumor size, regional lymph node metastasis, and TNM stage are all prognosis factors in breast cancer. On the other hand, we also analyzed prognosis effects of tumor characteristics (including estrogen receptor, progestrone receptor, HER2and Ki-67status) in these range of patients. Both estrogen receptor and progestrone receptor status, other than HER2and Ki-67, were prognosis factors in breast cancer, especially in patients without regional lymph node metastasis. Cox-regression analysis revealed tumor size, regional lymph node metastasis and tumor ER status were all independent prognostic factors of breast cancer.Conclusion:The age peak ranges from45-54years old in breast cancer patients in Eastern China. Tumor size, regional lymph node metastasis, estrogen receptor status were independent prognostic factors of breast cancer. |
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