Pregnancy After Kidney Transplantation With The Outcomes Of Mother And Newborn:a Retrospectively Review Study From A Single Center

Objective:To summarize all the recipients who successfully deliver after renal transplantation from The First affiliated Hospital of Zhejiang University, to investigate the effects of pregnancy on the maternal, fetal and graft.Methods:A retrospective analysis of the First affiliated Hospital of Zhejiang University nephrology Center since1992April to now, a total of12female renal transplant recipients delivered12healthy children. The data of recipients and their children were collected in the maternity hospital and the First affiliated hospital of Zhejiang University, including the type of kidney donor, the age of recipients at operation, interval time between transplantation and pregnancy, the use of immunosuppressive drugs during pregnancy, gestational age, maternal complications during pregnancy, childbirth and anesthesia, fetal birth and outcome of graft. Results:In12cases there are10cases of receptor (83.3%) received cadaveric renal transplantation,2patients (16.7%) received living renal transplantation, transplant operation at the age of (22.8±4.3) years old, transplant pregnancy interval was(5.5±2.9) years, during pregnancy in5cases (41.7%) use of Pred, Aza and CsA anti rejection,6cases (50%) use of Pred, Aza combined with Tac anti rejection,1cases were only used prednisone and azathioprine anti rejection, all fetuses were delivered by cesarean section through continuous epidural anesthesia,1cases with renal allograflt dysfunction and end up pregnancy in caesarean section at28weeks,6cases (50%) were premature,5cases of full-term, the male to female ratio of12children was6:6, mean birth weight was (2734±364) g,(48.1±3.1) cm height, the biparietal diameter size of (8.9±0.5) cm, Apgar score was (9.9±0.2), found no obvious abnormalities at birth, all children were artificial feeding, the largest age for at the age of18, most small for1month.12recipients in pregnancy and preeclampsia (including hypertension) in6cases, proteinuria in5cases,4cases of anemia, renal insufficiency in3cases,2cases of gestational diabetes mellitus.Conlusion:Renal transplant recipients can be pregnant after surgery, but there is a certain risk, it may affect the graft function. Closely follow-up during entire pregnancy form transplant physicians and obstetricians are required, choose the best time for pregnancy, close monitoring of the laboratory indexes during pregnancy, can finally improve the success rate of pregnancy after renal transplantation, brought home the gospel for the female patients of childbearing age uremia, women of child-bearing age who require renal replacement therapy, renal transplantation will in most cases restore fertility and offer the chance to start a family.