Analysis Of Drug Resistence Of395Mycobacterium Tuberculosis Patients With Posistive Sputum Culture

ObjectiveLearn initial treatment and rehabilitation Phlegm Mycobacterium tuberculosisculture-positive patients on a variety of drug-resistant TB cases, provide a scientificbasis for clinical treatment and medication tuberculosis, drug-resistant tuberculosis inorder to improve the current situation grim topic.MethodsSelect January1,2013-between31December2013, Jilin tuberculosis hospitalafter hospitalization for treatment of Mycobacterium tuberculosis in sputumculture-positive TB patients395cases for the study; ratio method recommended byWHO for strains16kinds of anti-TB drug resistance test; common bacterial cultureresults were judged according to criteria of the American clinical Laboratorystandards Committee (NC-CLS)1997put forward; the establishment of a databaseusing Epidata3.1, SPSS17.0statistical software for data statistical analysis,measurement data using central tendency and dispersion trends M (QL, QU) describethe data between the two groups were compared using the Wilcoxon test; count datarate and composition ratio between the two groups were compared using the χ2test,multiple influencing factors factors analyzed by Logistic regression.Results1. The present study investigated a total of395patients, aged a minimum of14years and a maximum of81years, the average age was47.0±19.0years.112women(28.4%),283were males (71.6%).102previously untreated patients,293patientswith retreatment. Retreatment early in age, sex and smoking or not the differenceswere not statistically significant (P>0.05).2. MDR of retreatment group(10.2%) was higher than early treatment group(2.9%),and the difference was statistically significant (P=0.026).3. There was no significant In the early treatment group or retreatment groupevery kinds of resistance rates. and resistance rates (17.4%) compared to retreatmentof patients, the difference was statistically significant (P=0.010). Second-line anti-TBdrugs, the retreatment rate of propylthiouracil in patients resistant to isoniazid andrifabutin amines in untreated patients, the difference was statistically significant(P=0.003, P=0.028).4. There was no significant in of all kinds of resistance rate by gender in patientswith in the early treatment group and or retreatment group (P>0.05). In the groupwithin40age, MDR was17.6%higher than the other two age groups (8.3%in the40-49age group,6.3%≥50years age group), the difference was statisticallysignificant (P=0.025).5.197patients with culture-positive bacteria as ordinary in395cases ofMycobacterium tuberculosis in sputum culture-positive tuberculosis patientshospitalized.The positive rate of Pseudomonas aeruginosa in patients with newlydiagnosed positive rate (7.1%) higher than the positive rate of retreatment (0), thedifference was statistically significant (P＝0.013).6. Respectively streptomycin, azithromycin, amoxicillin and other commonantibiotic resistance analysis for differences initial treatment group and retreatmentgroup in the antibiotic resistance rates were not statistically significant (P>0.05).7. Univariate logistic regression analysis showed that: treatment history only(early retreatment) and MDR-related (P=0.032), OR and OR95%CI of3.764(1.123,12.612)Conclusion1. At the beginning, the group retreated, first-line anti-TB drug resistance tostreptomycin and isoniazid mainly based. Retreatment rate and resistance to rifampinresistance rates were significantly higher than untreated patients, the second-lineanti-TB drugs, the resistance rates of retreatment in patients with propylthiouracilIsonicotinic amine and rifabutin was significantly higher than at the beginning treatedpatients. 2. MDR of retreatment groupwas higher than early treatment group. There was nosignificant in of all kinds of resistance rate by gender in patients with in the earlytreatment group and or retreatment group (P>0.05). In the group within40age, MDRwas17.6%high.3. The positive rate of Pseudomonas aeruginosa in patients with newly diagnosedpositive rate was higher than the positive rate of retreatment group.5. Retreatment was a risk factor for patients with MDR.