Qi Detoxification On Sepsis Shock, Clinical Research And The Experimental Research Of The Microcirculation

Objective: Observe qi detoxification efficacy in patients with sepsis shock, and theNew Zealand white rabbit improvement of microcirculation in sepsis shock, and itsfeasibility in the treatment of sepsis shock microcirculation for further discussion.Methods:1. Clinical study of60patients with sepsis shock were randomly dividedinto treatment group and control group, treatment group on the basis of conventionalwestern medicine treatment, respectively, in3h,12h to qi detoxification, the controlgroup given conventional western medicine treatment, observation of treatment in bothgroups0h,6h and h of TCM24symptoms integral APACHE score heart rate, meanarterial pressure (MAP),urine volume,oxygen partial pressure (PO2), alkali (BE) remainingblood oxygen saturation (SaO2) oxygenation index changes.2. Experimental study usingrabbit ear margin vein injection of lipopolysaccharide (LPS) to make New Zealand whiterabbit sepsis shock model, is only30New Zealand white rabbits were randomly dividedinto normal group and build module and10normal group, building modules wererandomly divided into treatment group and control group, each group of10only after1hin the building, the treatment group respectively in1h,2h given by gastric medicine,normal group and the control group given by gastric amount of distilled water monitoring0h,3h,6h mean arterial blood pressure heart rate of serum lactic acid (Lac), tumor necrosisfactor (TNF alpha) ET1levels change Through the BI-2000medical image analysissystem to observe3h,6h sepsis shock the New Zealand white rabbit mesenteric microvein diameter velocity flow open capillary network node number, to observe the influence of the indicators on the qi detoxification party.Results:1. Clinical studies have shown that qi detoxification party obviously improvethe treatment group of TCM symptoms integral APACHE score heart rate, mean arterialpressure, urine volume,serum lactic acid level, and the control group was statisticallydifference (P <0.05), the clinical curative effect of treatment group is better than that ofcontrol group (P <0.05)2. Studies have shown that qi detoxification can significantlyimprove the treatment group sepsis shock New Zealand white rabbits mean arterialpressure the heart rate of serum lactic acid serum TNF alpha serum level of ET1andmesenteric microcirculation arteriovenous diameter velocity flow open capillary networknode number, compared to building control group was statistically difference (P <0.05).Conclusion:1. Sepsis shock exists microcirculation dysfunction.2. Qi detoxificationcan obviously improve sepsis shock and microcirculation.