Association Of Serum Osteoprotegerin Levels With Carotid Atherosclerotic Plaque In Acute Ischaemic Stroke Patients

Objective: The research compares cerebral infarction(CI) patients with different types of the carotidplaques group to the healthy control group of serum osteoprotegerin(OPG) levels, observe the relationshipbetween OPG levels and cerebral infarction and the stability of carotid atherosclerotic plaque.Methods: Selected cerebral infarction patients from November2012to August2013neurology departmentin hospital96cases,with screen for carotid plaque by duplex color Doppler and then classified into plaquesgroup(64patients) and no plaques group(32patients).The stable plaques group(30patients) and unstableplaques group(34patients) were further classified,while collected31normal controls. Serumosteoprotegerin levels were measured by using enzyme-linked immunoassay(ELISA).Statistical analysiswas performed using SPSS17.0statistical software,observed the level of OPG between the cerebralinfarction group and the healthy control group, and analysis of the stable level of carotid plaque in patientswith cerebral infarction at different OPG concentration changes,as well as the correlation between OPG incerebral infarction patients with general index.Results: In the four groups,OPG levels had significant difference (P＜0.05).The OPG in control groupwas lower than the other three groups,the difference was statistically significant (P＜0.05);The OPG inun-plaques group was lower than stable plaques group,the difference was statistically significant (P＜0.05);The OPG in stable plaques group was lower than unstable plaques group,the difference wasstatistically significant (P＜0.05).Correlation analysis showed:CRP, Hcy and serum OPG were positivelycorrelated (P＜0.05).Conclusion:Serum OPG levels associated with cerebral infarction. Serum OPG associated with carotidatherosclerotic plaque instability.