Many Times A Day Insulin Injections To Explore The Role Of Oxidative Stress In Type2Diabetes Status

Objective: Explore insulin intensive therapy in patients with type2diabetes outside the hypoglycemiceffect, expect that insulin intensive therapy in patients with type2diabetes in addition to the hypoglycemiceffect and anti-inflammation, inhibition of platelet aggregation, and so on, can improve patients’ glucosemetabolism, insulin resistance and vascular function, the timing of insulin intensive therapy of diabeticpatients, and to provide theoretical reference clear its hypoglycemic effect.Methods: Selected between January2013and June2013, the first affiliated hospital of xinjiang shiheziuniversity endocrinology,112cases of hospitalized patients with type2diabetes, general information andcomplications in patients with records. Cases in patients admitted to hospital24hours by fasting serum,using automatic biochemical analyzer test, blood lipid, fasting glucose levels glycosylated hemoglobin(HbA1c), fasting C peptide, hypersensitive c-reactive protein (Hs-CRP), and other indicators, ELISAmethod to determine the plasma platelet-derived growth factor-AA (PDGF-AA),8-differentprostaglandins F2α (H8PF2α), and to give multiple subcutaneous insulin injection in patients withhypoglycemic, timely adjustment of insulin dosage according to blood glucose testing condition. Insulinintensive treatment7take the specimens were again in the future, more insulin intensive treatment beforeand after the Hs CRP, PDGF-AA, H8PF2α level of change; Further study on the Hs-the relationshipbetween CRP and insulin beta cell function index, respectively discusses the Hs CRP, PDGF-AA,H8PF2αthe influence factors of alpha.Results:(1) Patients before and after insulin intensive treatment serum Hs-CRP (t=7.686, P <0.001),PDGF-AA(t=5.820, P <0.001), H8PF2α level (t=2.682, P=2.682) than before treatment significantlydecreased;(2)To do the Hs-CRP levels should be variable in the multivariate Logistic regression analysisfound that smoking history (OR=2.687, P=2.687) and merge two OR more chronic diseases (OR=2.479,P=2.479) are the Hs-a risk factor for increased CRP;(3) To do PDGF-AA levels should be variable multiple Logistic regression analysis found thatH8PF2α (OR=1.024, P=1.024) and HbA1c (OR=1.248, P <0.001) as a risk factor for increased PDGF;(4) To H8PF2α levels do the dependent variable multiple Logistic regression analysis found thatHbA1c (OR=1.417, P=1.417) and PDGF-AA were H8PF2α (OR=1.007, P=1.007), higher riskfactors;(5) The HbA1c>9%group of Hs-CRP (10.60±6.98mg/L) IS HbAlc <7%group (7.38±4.75mg/L) and HbAlc7%to9%(6.09±3.68mg/L) significantly increased (F=8.325, P=8.325), Homa IS (F=0.863, P=0.001), HbA1c (F=0.36, P=0.36) and the Hs-there was a negative correlation CRP.Conclusions:(1)Insulin intensive treatment in addition to the hypoglycemic effect and anti-inflammation,inhibition of platelet aggregation effect;(2) Smoking and type2diabetes mellitus and2kinds of chronic diseases associated with Hs-elevated CRP, prompt diabetic blood glucose management more standard when a variety of chronic diseases;(3) High HbA1c, or poor blood sugar control for a long time is H8PF2α, the influencefactors of PDGF-AA, confirmed the long-term in a state of oxidative stress, inflammation, diabetes,activation in patients with multiple pathways leading to chronic complications;(4) H8PF2α,PDGF-AA each influence factor, clew inflammation and platelet aggregation inthe process of the development of diabetic chronic complications have the function of mutual promotion;(5) The Hs-CRP and negatively correlated with HomaIS and HbA1c index, can be roughlyislet beta cell function in patients with evaluation.