The Expression Of MMP-9Serum Of Myocardial Infarction Patients Characteristics And Kidney Invigorate The Circulation Of Intervention Effect Of Traditional Chinese Medicine Research

Objective1.To observe the myocardial infarction patients serum matrix metalloproteinases-9(MMP-9) expression,analysis of variation characteristics of MMP-9.2.Observe kidney invigorate the circulation of Chinese traditional medicine serum inpatients with myocardial infarction (MI) expression of MMP-9,provide the basis for prevention and treatment of coronary heart disease (CHD) of traditional Chinese medicine.Methods1.Choice of36patients with acute myocardial infarction(AMI),20patients withchronic myocardial infarction,10cases of healthy controls.1h,24h after admission,3d,5d,7dand14d acquisition elbow venous blood.Enzyme-linked immunosorbent (ELISA) to detectthe contents of serum levels of MMP-9,immune turbidimetry detection of c-reactiveprotein (CRP) and western blot method to detect troponin I(CTnI).2.Select36cases of AMI patients were randomly divided into kidney invigorate thecirculation of Chinese traditional medicine group and the control group,18cases in eachgroup. Kidney invigorate the circulation of Chinese traditional medicine group was givenconventional western medicine with kidney invigorate the circulation of traditionalChinese medicine therapy, the control group given conventional western medicinetreatment,observation2weeks.To detect the contents of MMP-9,at the same timeobservation of traditional Chinese medicine symptom integral, electrocardiogram (ECG)changes. Results1.The expression of MMP-9different types of AMI patients Hospital1h after AMIpatients serum levels of MMP-9expression level (123.14±36.06) is significantly higherthan chronic myocardial infarction patients (70.80±23.41) and healthy people(44.38±21.60)(P<0.01),and the expression of MMP-9old AMI patients than healthycontrols (P<0.05).2.AMI patients with different time window the expression of MMP-9AMI patientsserum levels of MMP-9expression levels continue to rise in3days after admission,fivedays of peak and gradually decline,after7days continues to fall,to14days was significantlylower than1h after admissi on (P<0.01),and reached normal levels.3.The expression of MMP-9patients with AMI,CTnI and the relationship between theCRP CTnI and expression of CRP in1h after admission,the rise,24h peak,there are still express3d,7d to during1h level.Expression of MMP-91h after admission by correlation analysis and the expression of CTnI and CRP level was positively correlation (r=0.752,P<0.01,r=0.767,P<0.01).4.The doctor of traditional Chinese medicine syndrome curative effect Kidneyinvigorate the circulation of Chinese traditional medicine group symptom curative effectthe total effective rate was88.89%in the cont rol group total effective rate was55.56%,therank and inspection,the total effective rate had significant difference(P<0.01).5.The doctor of traditional Chinese medicine syndrome curative effect Kidney invigorate the circulation of Chinese traditional medicine group of electrocardiogram(ECG) to improve the total effective rate was83.33%,control group total effective rate was61.11%,therank and inspection,thetotal effective rate exists significant difference(P<0.05).6.Kidney invigorate the circulation of traditional Chinese medicine (TCM) impact onthe level of MMP-9Kidney invigorate the circulation of Chinese traditional medicinegroup of MMP-9levels before and after the treatment were120.68±33.25,54.12±16.59compared by t test before and after treatment was statistically difference(P<0.01),kidneyinvigorate the circulation of Chinese traditional medicine group and control group aftertreatment of MMP-9content were54.12±16.59,85.86±21.58,by t test,the treatment wasstatistically significant difference(P<0.05).Conclusion1.Early expression of MMP-9patients with acute myocardial infarction and elevatedCTnI,the change of CRP basic consistent,but high expression period last longer,can be used as the prediction of early myocardial infarction,and the judge index of the diseaseprocess.2.Kidney invigorate the circulation of Chinese traditional medicine can reduce themyocardial infarction patients,the serum levels of the expression of MMP-9can improvethe TCM symptoms of kidney and blood stasis type AMI patients,ecg manifestations,isimportant in the clinical treatment of coronary heart disease,myocardial infarction method.