The Study On The Relationship Of Intrauterine Infection And Brain Injury In Preterm Infants

OBJECTION:By gathering and detection of the associated inflammation factors of the brain injury in preterm infants, analyze the relationship between the brain injury in preterm infants and intrauterine infection. METHODS:Collected 60 cases of obstetric born ≤34 weeks gestational age preterm children, comprehensive analyze the maternal and fetal infection factors of inflammation, and analyze the relationship between the brain injury in preterm infants and intrauterine infection. RESULTS: 1. 24 cases of the group of maternal chorioamnionitis, which occurred MRI diagnosis of brain injury in preterm children, 18 cases of the group of non-brain damage in preterm children, BIPI incidence of 75%; 36 cases of chorioamnionitis, which 6 cases of occurred MRI diagnosis of brain injury in preterm children, non-brain damage in preterm children 30 cases, BIPI incidence of 16.7%, the two groups were in preterm children and the incidence of brain was statistically significant(χ2=16.34, p<0.01). 2. IL-6, TNF-α within 24 hours in premature infants chorioamnionitis and umbilical cord increases brain damage. 3. IL-10 within 24 hours in the event of the occurrence of chorioamnionitis and umbilical cord the expression of brain injury in premature children is reduced. 5. Prenatal maternal blood within 24 hours of IL-6 diagnosis of brain injury in preterm children sensitivity and specificity were 54%, 89%; TNF-α diagnose brain injury in preterm children sensitivity and specificity were 62%, 97%; umbilical Cord sensitivity and specificity of IL-6 brain injury in preterm children were diagnosed 75%; TNF-α diagnose brain injury in preterm children sensitivity and specificity were 25%, 94%. 6. Using Logistics regression analysis, maternal prenatal maternal blood 24 hours pregnant expression of TNF-α is chorioamnionitis and premature child brain injury risk factors; And the prenatal maternal expression of IL-10 within 24 hours amount is a protective factor of brain damage in premature children. CONCLUSIONS: 1. Intrauterine infection is an important factor in causing brain damage in preterm children; 2 IL-6, TNF-α is the occurrence of chorioamnionitis, the risk factors of brain injury in premature children; 3. IL-10 occurred chorioamnionitis, protective factors of brain injury in premature children. [Key Words] Brain injury in preterm infants; Interleukin-6; Interleukin-10; Tumor...