Association Between Polymorphisms Of Furin Gene And Metabolic Syndrome In Uygur Population

Objectives:to investigate the relationship between Furin gene polymorphism and abnormal metabolc desease in Xinjiang Uygur population. Methods:according to different plasma glucose levels, Waist circumference, body mass index, blood glucose level, blood pressure, blood lipids levels,1134 individual in xinjiang hetian area were divided into 2 groups that is 707 patients with MetS and 474 non-MetS subjects.selectingn representative variant in application of TaqMan-PCR in a large population of genotype identification and case-control study. Based on HapMap and NCBI databases we selected the polymorphismr rs2071410 SNP (htSNP) sufficiently covering the genetic variation of the whole gene. We therefore examined the association between rs2071410 Furin and in the Xinjiang Uygur population in two independent study populations; The genotype and allele frequencies and relative clinic data were compared among groups.Results:The rs2071410 variant was associated with MetS in Uygur subjects (P=0.010). Logistic regression analysis indicated that TT genotype of rs2071410 variation is a risk factor for MetS (OR=1.471,P=0.013).Further analysis found that the level The blood pressure, blood sugar, LDL, SBP related to homozygote TT are higher than CC and CT, that is to say the role of homozygote TT was Increase the risk of MetS. Conclusions:Our study suggested that the rs2071410 polymorphism of Furin gene is associated with MetS in ethnic Uygur population from Xinjiang,China.