The Clinic Research Of Heparin Sensitivity Between Different Ethnic Groups Of The Patients With Heart Surgery

Objective:To investigate the heparin sensitivity and the difference of dosage of heparin during different ethnic groups of the patients with heart surgery. Methods: Selecting 293 cases of patients with heart surgery under the general anesthesia Cardiopulmonary Bypass, among them 109 cases of the Uighurs ethnic group,86 cases of Kazak ethnic group,98 cases of Han ethnic group. Detecting preoperative basis ACT, giving heparin 2mg/kg for the first time, adding heparin 0.5mg/kg to 3mg/kg successively, monitoring the ACT of different doses of heparin, recording the patients’general data, amount of blood transfusion and postoperative 24h blood loss. Results:ACT is different under the different doses of heparin among different ethnic groups of the patients. The ACT of Uighur ethnic and Kazakh ethnic are higher than Han ethnic obviously, there is obvious statistical significance(P<0.05);The comparison of the patients proportion of ACT> 400s under heparin dose 2mg/kg during different ethnic groups. Uighur ethnic, Kazakh ethnic and Han ethnic respectively accounted for 82.56%,84.88% and 77.55%;To the postoperative 24h blood loss, Uighur ethnic and Kazakh ethnic are less than Han ethnic obviously (P<0.05), but there is no statistical significance between Uighur ethnic and Kazakh ethnic(P>0.05). Conclusion:There is different sensitivity to the same dose of heparin during different ethnic groups. The sensitivity of heparin in Han ethnic patients is less than Uighur ethnic patients and Kazakh ethnic patients,and the postoperative blood loss is more than the other two groups.